{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:50:44Z","timestamp":1788576644354,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH113477"],"award-info":[{"award-number":["MH113477"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P30MH062512"],"award-info":[{"award-number":["P30MH062512"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We compared new <jats:italic>Aspergillus<\/jats:italic> Galactomannan Lateral Flow Assay with the newly formatted <jats:italic>Aspergillus\u2010<\/jats:italic>specific Lateral Flow device tests for the diagnosis of invasive pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>) in non\u2010neutropenic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed both tests in 82 bronchoalveolar lavage fluid samples from 82 patients at risk for <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> but without underlying haematologic malignancy. Samples were collected between September 2016 and September 2018 at the University of California San Diego, United States. <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> was classified following two published consensus criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Classification of cases varied widely between the two consensus criteria. When using criteria established for the intensive care unit, 26\/82 patients (32%) met criteria for proven or putative <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>. Both point\u2010of\u2010care assays showed sensitivities ranging between 58% and 69%, with specificities between 68% and 75%. Sensitivity increased up to 81% when both tests were combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study outlines the need for updated, unified and more broadly applicable consensus definitions for classifying <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content> in non\u2010neutropenic patients, a work that is currently in progress. Both point\u2010of\u2010care tests showed comparable performance, with sensitivities and specificities in the 60%\u201070% range when used alone and increasing to 80% when used in combination. The new point\u2010of\u2010care tests may serve a role at the bedside in those with clinical suspicion of <jats:styled-content style=\"fixed-case\">IPA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12881","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T07:39:31Z","timestamp":1545205171000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Point\u2010of\u2010care diagnosis of invasive aspergillosis in non\u2010neutropenic patients: <i>Aspergillus<\/i> Galactomannan Lateral Flow Assay versus <i>Aspergillus<\/i>\u2010specific Lateral Flow Device test in bronchoalveolar lavage"],"prefix":"10.1111","volume":"62","author":[{"given":"Jeffrey D.","family":"Jenks","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay R.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Taplitz","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Aslam","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Diego  San Diego California"},{"name":"Department of Pathology University of California San Diego  San Diego 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