{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:23:29Z","timestamp":1792301009294,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013881","name":"Giellepi S.p.A.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013881","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vulvovaginal candidiasis (\n                      <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                      ) is a recurrent vaginal condition in childbearing women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to assess the efficacy of an oral formulation containing\n                      <jats:italic>Lactobacillus acidophilus<\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GLA<\/jats:styled-content>\n                      \u201014,\n                      <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">HN<\/jats:styled-content>\n                      001 and bovine lactoferrin on symptoms and recurrence of\n                      <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                      as adjuvant therapy to topical clotrimazole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight women positive for\n                      <jats:italic>C. albicans<\/jats:italic>\n                      , symptoms of\n                      <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                      and documented history of recurrences were randomised into 2 groups receiving verum or placebo (2 capsules\/day for 5\u00a0days followed by 1 capsule\/day for additional 10\u00a0days) as adjuvant treatment to clotrimazole (induction phase) followed by a maintenance cycle of 6\u00a0months (1 capsule\/day verum or placebo for 10 consecutive days each month). Symptoms, overall cure rate and recurrence rate were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After clotrimazole therapy, a significant improvement of symptoms was shown in both groups. However, only women treated with probiotics and lactoferrin showed a significant improvement of itching and discharge at 3 and 6\u00a0months. During the six\u2010month follow\u2010up, recurrences were significantly less in the intervention group vs placebo (33.3% vs 91.7% after 3\u00a0months and 29.2% vs 100% after 6\u00a0months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results show that the investigated lactobacilli mixture in combination with lactoferrin represents a safe and effective adjuvant approach for reducing symptoms and recurrences of\n                      <jats:styled-content style=\"fixed-case\">RVVC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.12883","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T07:43:52Z","timestamp":1545205432000},"page":"328-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5451-2691","authenticated-orcid":false,"given":"Rosario","family":"Russo","sequence":"first","affiliation":[{"name":"Giellepi S.p.A. 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