{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:19:09Z","timestamp":1789611549115,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term oral triazole antifungal therapy is the cornerstone of management for patients with chronic pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>). Itraconazole is the first\u2010line choice of treatment. Voriconazole, posaconazole or isavuconazole can be used as alternative treatments in case of resistance or intolerance. All of these can cause significant adverse drug reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate how <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> patients tolerate voriconazole and isavuconazole after prior triazole therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective observational study at the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> National Aspergillosis Centre. Medical records for all consecutive <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> patients started on isavuconazole and voriconazole during an observation period of 12 and 6\u00a0months respectively were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During this study period, 20 patients were started on isavuconazole and 21 patients on voriconazole. Adverse events were seen in 18 of 21 (86%) the patients in the voriconazole group and 12 of 20 (60%) in the isavuconazole group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). For those who developed adverse events to these agents, the rates of discontinuation of therapy were comparable (ie 10\/18 [56%], voriconazole vs 8\/12 [67%], isavuconazole; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.54). Five (25%) patients in the isavuconazole group who were intolerant to other triazoles tolerated the standard dose of isavuconazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with isavuconazole, adverse events were significantly higher in <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> patients commenced on voriconazole. Isavuconazole may be an option for those patients who are intolerant to other triazoles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12885","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T13:46:59Z","timestamp":1545313619000},"page":"217-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Isavuconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A retrospective comparison of rates of adverse events"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4515-8517","authenticated-orcid":false,"given":"Felix","family":"Bongomin","sequence":"first","affiliation":[{"name":"National Aspergillosis Centre ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Division of Infection, Immunity and Respiratory Medicine Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Maguire","sequence":"additional","affiliation":[{"name":"Mycology Reference Centre Manchester ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B.","family":"Moore","sequence":"additional","affiliation":[{"name":"Mycology Reference Centre Manchester ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Felton","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Acute Intensive Care Unit Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riina","family":"Rautemaa\u2010Richardson","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Mycology Reference Centre Manchester ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Department of Infectious Diseases Wythenshawe Hospital Manchester University NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.11.089441"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.06.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1652"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015581679"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0652-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt508"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70006-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw119"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2015.1020544"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.12885","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:26:29Z","timestamp":1694273189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/myc.12885"],"URL":"https:\/\/doi.org\/10.1111\/myc.12885","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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