{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:42:00Z","timestamp":1784263320512,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["FAPERGS \u2010 EDITAL 04\/2016 \u2010 PRONUPEQ 2016"],"award-info":[{"award-number":["FAPERGS \u2010 EDITAL 04\/2016 \u2010 PRONUPEQ 2016"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clioquinol was used in the 1950s\u20101970s as antimicrobial but its oral formulations were withdrawn from the market due to suspected neurotoxicity. Currently, there is possibility of repositioning of oral clioquinol formulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the antifungal activity and toxicological parameters of clioquinol and the other two 8\u2010hydroxyquinoline derivatives using alternative animal models and to study the interaction dynamic of clioquinol with <jats:italic>Candida albicans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used Toll\u2010deficient <jats:italic>Drosophila melanogaster<\/jats:italic> to test the protective effect of 8\u2010hydroxyquinolines against <jats:italic>C.\u00a0albicans<\/jats:italic> infection. Toxicological parameters were investigated in chicken embryo. A mathematical model\u2010based analysis of the time\u2010kill data of clioquinol was performed to obtain pharmacodynamic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clioquinol fully protected <jats:italic>D.\u00a0melanogaster<\/jats:italic> from the infection. The 8\u2010hydroxyquinolines did not cause changes in opening of the beak and movement of the chicken embryo; however, clioquinol and compound <jats:bold>2<\/jats:bold> increased arterial pulsation. Compound <jats:bold>3<\/jats:bold> was lethal at 1\u00a0mg\u00a0mL<jats:sup>\u22121<\/jats:sup>. Effective concentration found in modelling indicated that clioquinol was highly effective against <jats:italic>C.\u00a0albicans<\/jats:italic> (0.306\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup>) in easily achievable serum levels; clioquinol rapidly achieved kill rate reaching the maximum effect after 13\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results support the potential of clioquinol to be used as a systemic antifungal agent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12888","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T06:09:10Z","timestamp":1546409350000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral clioquinol is effective in the treatment of a fly model of <i>Candida<\/i> systemic infection"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-6327","authenticated-orcid":false,"given":"Bruna","family":"Pippi","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Microbiologia Agr\u00edcola e do Ambiente Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Merkel","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Farmacologia e Terap\u00eautica Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli Jaqueline","family":"Staudt","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Lettieri","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia Instituto Federal Catarinense  Conc\u00f3rdia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana Verlindo","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis Adriel","family":"Zanette","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas: Farmacologia e Terap\u00eautica Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Fernandes","family":"Andrade","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Microbiologia Agr\u00edcola e do Ambiente Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Meneghello","family":"Fuentefria","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Microbiologia Agr\u00edcola e do Ambiente Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S40160"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181920ffd"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkPediatriArs.2017.5291"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"130","article-title":"Antifungal agents: mode of action in yeast cells","volume":"19","author":"Carrillo\u2010Mu\u00f1oz AJ","year":"2006","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02146.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.08.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90004-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-017-0455-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.23937\/2378-3419\/3\/1\/1037"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00253"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70262-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.05.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2018.07.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2018.08.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12082"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.02.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600621204"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/500950"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021166500169"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.157"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079671"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.10.004"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2002.9488"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005769"},{"key":"e_1_2_7_28_1","first-page":"426","article-title":"Pharmacokinetic\u2010pharmacodynamic modelling of the in vitro antiinfective effect of piperacillin\u2010tazobactam combinations","volume":"35","author":"Dalla Costa T","year":"1997","journal-title":"Int J Clin Pharmacol Ther"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2003.07.009"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.05.005"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90037-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)80056-9"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92699-7"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.12888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:49:46Z","timestamp":1694357386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,26]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/myc.12888"],"URL":"https:\/\/doi.org\/10.1111\/myc.12888","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,26]]},"assertion":[{"value":"2018-12-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}