{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:07:06Z","timestamp":1791414426258,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571970"],"award-info":[{"award-number":["81571970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Fonsecaea monophora<\/jats:italic> is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between <jats:italic>F.\u00a0monophora<\/jats:italic> and host. The aim of this study was to explore the potential mechanism of macrophages against <jats:italic>F.\u00a0monophora<\/jats:italic>, especially the role of melanin during the pathogenic process. We carried out <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing based on the Illumina system. It showed that according to melanin contents, different strains of <jats:italic>F.\u00a0monophora<\/jats:italic> induced different transcriptional profilings in macrophages. Functional analyses suggested the biological functions of differentially expressed genes were closely related to immune response, and the melanin might affect the interactions by regulating the <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> signalling pathway of macrophages. Our results provide insights into the pathogenesis of infection by <jats:italic>F.\u00a0monophora<\/jats:italic> conidia.<\/jats:p>","DOI":"10.1111\/myc.12894","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T03:01:17Z","timestamp":1547780477000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transcriptional profiling of macrophages infected with <i>Fonsecaea monophora<\/i>"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-4125","authenticated-orcid":false,"given":"Minglan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Dermatology and Venereology Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiufeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and Prevention  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-7134","authenticated-orcid":false,"given":"Jinglin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou 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