{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:44:16Z","timestamp":1768625056663,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["91\/74"],"award-info":[{"award-number":["91\/74"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) is associated with increased rates of morbidity and mortality due to fungal and bacterial colonisation of the airways or respiratory infections. The prevalence of fungi in Iranian <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> population has been underestimated. Therefore, the current study was conducted to define the frequency of fungi in respiratory specimens obtained from Iranian <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients based on conventional and molecular assays. Furthermore, in vitro antifungal susceptibility testing was performed on the obtained isolates according to the guidelines from the Clinical and Laboratory Standards Institute. A cohort of 42 <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients, including 29 males and 13 females, were categorised according to the referenced diagnostic criteria. <jats:italic>Candida albicans<\/jats:italic> (n\u00a0=\u00a024, 80%), <jats:italic>C.\u00a0dubliniensis<\/jats:italic> (n\u00a0=\u00a02, 6.6%), <jats:italic>C.\u00a0parapsilosis<\/jats:italic> (n\u00a0=\u00a02, 6.6%), <jats:italic>C.\u00a0tropicalis<\/jats:italic> (n\u00a0=\u00a01, 3.3%), <jats:italic>C.\u00a0glabrata<\/jats:italic> (n\u00a0=\u00a01, 3.3%) and <jats:italic>Meyerozyma caribbica<\/jats:italic> (n\u00a0=\u00a01, 3.3%) were isolated from 73.8% of the <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients. <jats:italic>Aspergillus terreus<\/jats:italic> (n\u00a0=\u00a03, 42.8%) was identified as the most common <jats:italic>Aspergillus<\/jats:italic> species, followed by <jats:italic>A.\u00a0fumigatus<\/jats:italic> (n\u00a0=\u00a02, 28.5%), <jats:italic>A.\u00a0oryzae<\/jats:italic> (n\u00a0=\u00a01, 14.2%) and <jats:italic>A.\u00a0flavus<\/jats:italic> (n\u00a0=\u00a01, 14.2%). Bacterial and fungal co\u2010colonisation was detected in 7 (16.6%) and 22 (52.3%) samples that were positive for <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> species, respectively. However, <jats:italic>Scedosporium<\/jats:italic> species and <jats:italic>Exophiala dermatitidis<\/jats:italic> never were detected. In terms of geometric mean (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) minimum inhibitory concentrations (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s), posaconazole (0.018\u00a0\u03bcg\/mL) and caspofungin (0.083\u00a0\u03bcg\/mL) exhibited the highest antifungal activities against all <jats:italic>Candida<\/jats:italic> species. In addition, posaconazole exhibited the lowest <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> range (0.008\u20100.063\u00a0\u03bcg\/mL) against all <jats:italic>Aspergillus<\/jats:italic> species, followed by caspofungin (0.016\u20100.125\u00a0\u03bcg\/mL) and voriconazole (0.125\u20100.25\u00a0\u03bcg\/mL). To conclude, it is essential to adopt a consistent method for the implementation of primary diagnosis and determination of treatment regimen for the <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients. However, further studies are still needed to better define the epidemiology of fungal organisms in <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients from the Middle East and the clinical significance of their isolation.<\/jats:p>","DOI":"10.1111\/myc.12898","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T14:04:59Z","timestamp":1548425099000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Airway colonisation by <i>Candida<\/i> and <i>Aspergillus<\/i> species in Iranian cystic fibrosis patients"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9963-7084","authenticated-orcid":false,"given":"Elahe","family":"Nasri","sequence":"first","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti University of Medical Sciences  Tehran 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Daneshvari Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-7446","authenticated-orcid":false,"given":"Fatemeh","family":"Ahangarkani","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melika","family":"Laal kargar","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Abtahian","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti University of Medical Sciences  Tehran 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