{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:31:18Z","timestamp":1790685078793,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients treated for invasive aspergillosis may relapse during subsequent periods of immunosuppression and should receive secondary prophylaxis. Little is known about the frequency of relapse and practices of secondary prophylaxis for invasive fusariosis (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate practices of secondary prophylaxis and the frequency of relapse in patients who survived <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> and were exposed to subsequent periods of immunosuppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre retrospective study of patients with haematological malignancies who developed <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>, survived the initial fungal disease period, and were exposed to subsequent periods of immunosuppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 40 patients, 35 received additional chemotherapy and developed neutropenia (median, 24\u00a0days; range, 4\u2010104), and five received glucocorticoids for the treatment of graft\u2010vs\u2010host disease. Overall, 32 patients received secondary prophylaxis (voriconazole in 24) for a median of 112\u00a0days (range, 12\u2010468). <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> relapsed in five patients (12.5%): 2\/8 (25%) not on prophylaxis and 3\/32 (9.4%) receiving prophylaxis. Among 28 patients with disseminated <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>, relapse occurred in 2\/2 (100%) not on prophylaxis and in 3\/26 (11.5%) on prophylaxis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). All patients who relapsed <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> who survive the initial disease may relapse if exposed to subsequent episodes of immunosuppressive therapies. Secondary prophylaxis should be considered, especially if <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> was disseminated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12901","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T17:28:19Z","timestamp":1549387699000},"page":"413-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes of patients with invasive fusariosis who undergo further immunosuppressive treatments, is there a role for secondary prophylaxis?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-0014","authenticated-orcid":false,"given":"Marcio","family":"Nucci","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Shoham","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Abdala","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Rico","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Forghieri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Section of Hematology University of Modena and Reggio Emilia Azienda Ospedaliero\u2010Universitaria di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Nou\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cappellano","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Federal University of S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Solza","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Pedro Ernesto Universidade do Estado do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancer Jos\u00e9 de Alencar Gomes da Silva (INCA)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Nadali","sequence":"additional","affiliation":[{"name":"Hematology Unit Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Nucci","sequence":"additional","affiliation":[{"name":"Department Hematology Fluminense Federal University  Niter\u00f3i Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo L.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Federal University of S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Munhoz","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Hospital Federal da Lagoa  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Queiroz\u2010Telles Filho","sequence":"additional","affiliation":[{"name":"Department of Public Health Federal University of Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos B. 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