{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:23:19Z","timestamp":1793046199457,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Many patients with histoplasmosis are treated with anti\u2010tubercular therapy (\n ATT<\/jats:styled-content>\n ) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary\n Histoplasma<\/jats:italic>\n antigen detection test.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary\n Histoplasma<\/jats:italic>\n antigen detection test were analysed in this single centre retrospective study.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010seven patients (18 in Period A, and 19 patients in Period B) were studied. There was nearly a threefold increase in diagnoses (from 0.39 cases to 1.18 cases per month) after the introduction of antigen test. Nine patients (24.3%) were immunocompromised (6 had\n HIV<\/jats:styled-content>\n infection and 3 were on steroids), and 28 (75.6%) were immunocompetent. Empirical\n ATT<\/jats:styled-content>\n had been given to 10 patients prior to histoplasmosis diagnosis. Invasive tissue sampling was required in only two patients in Period B to confirm the diagnosis. Immunocompromised patients were younger, were more likely to have skin and mucosal findings, anaemia and leucopenia as compared to immune\u2010competent patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study emphasises that histoplasmosis cases may be missed and patients may receive\n ATT<\/jats:styled-content>\n unnecessarily.\n Histoplasma<\/jats:italic>\n antigen increased the diagnostic yield by almost threefold in our study.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.12902","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T07:59:44Z","timestamp":1549612784000},"page":"502-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-6293","authenticated-orcid":false,"given":"Nitin","family":"Bansal","sequence":"first","affiliation":[{"name":"Infectious Diseases Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Sethuraman","sequence":"additional","affiliation":[{"name":"Microbiology Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatasubramanian","family":"Ramasubramanian","sequence":"additional","affiliation":[{"name":"Infectious Diseases Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Kumar D","sequence":"additional","affiliation":[{"name":"Infectious Diseases Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthur","family":"Nambi P","sequence":"additional","affiliation":[{"name":"Infectious Diseases Apollo Hospitals Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Microbiology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"e_1_2_7_3_1","first-page":"25","article-title":"Histoplasmosis in India: truly uncommon or uncommonly recognised?","volume":"60","author":"Gopalakrishnan R","year":"2012","journal-title":"J Assoc Physicians 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