{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:03Z","timestamp":1747187103236,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>False positivity of antigen immunoassays used as an early diagnostic tool to detect invasive fungal infections is known. Interpretation of the assay needs the identification of sources which could affect the specificity of the test. We focused on the influence of parenteral nutrition (PN) and piperacillin\u2010tazobactam (TZP) on fungal immunoassays. Measurable amounts of <jats:italic>Candida<\/jats:italic> antigen mannan were detected in several compounds of PN and TZP in a previous in vitro study. In the current study, 84 patients undergoing allogeneic haematopoietic cell transplantation receiving either TZP, PN or both were monitored with <jats:italic>Aspergillus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> antigen assay. Six patients were analysed closer in a kinetic analysis with more frequent blood sampling to detect mannan. PN in diverse compositions as well as TZP did not increase significantly the amount of mannan and the <jats:italic>Aspergillus<\/jats:italic> antigen in serum. We could not confirm the positive results of the in vitro study. Physicians should be aware that mannan antigenemia due to drug infusion could be a transient issue and should be considered in the interpretation of fungal immunoassays, although we could not find clinically relevant effects on mannan levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12921","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:51:31Z","timestamp":1556671891000},"page":"576-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["False\u2010positive <i>Candida<\/i> and <i>Aspergillus<\/i> antigen testing in recipients of allogeneic haematopoietic cell transplantation due to administration of parenteral nutrition and fixed combinations of piperacillin\u2010tazobactam"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1800-2330","authenticated-orcid":false,"given":"Wencke","family":"Walter","sequence":"first","affiliation":[{"name":"Klinik\u2010Apotheke Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Knoth","sequence":"additional","affiliation":[{"name":"Klinik\u2010Apotheke Universit\u00e4tsklinikum Carl Gustav Carus an der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr407"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/943691"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.512300"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw444"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02040.x"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"53","article-title":"Systemic fungal infections\u2014new approaches for diagnosis and treatment","volume":"32","author":"M\u00fcller FM","year":"2003","journal-title":"Klinikarzt"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12841"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/382224"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4744-4748.2004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl334"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2011.10.018"},{"issue":"6","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/iai.60.6.2237-2245.1992","article-title":"Rat monoclonal antibodies against Aspergillus galactomannan","volume":"60","author":"Stynen D","year":"1992","journal-title":"Infect Immun"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702009000500007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2370-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02131.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks111"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00285-14"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0003-6"},{"key":"e_1_2_9_20_1","unstructured":"HuppmannS.Inzidenz und Letalit\u00e4t invasiver Mykosen bei Hochrisikopatienten mit akuter myeloischer Leuk\u00e4mie. 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