{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:58Z","timestamp":1787015698391,"version":"build-2736575974"},"reference-count":81,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Invasive aspergillosis (\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    ) is a serious hazard to haematological and critical care patients. Impactful risk factors for developing\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    have been characterised; however, systematic analysis of baseline prognostic factors for treatment course of\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    is missing. To understand prognostic variables, we analysed original articles identifying baseline factors that predict treatment outcome in patients with\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    . PubMed database was searched for publications since database inception until May 2018. Inclusion criteria were published baseline prognostic factors present at the diagnosis of\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    . In total, 58 studies from 267 centres reported 7320 patients with\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    and 40 different predictors. Unfavourable predictors in medical history were kidney (7.4%, 10\/136) and liver failure (3.7%, 5\/136),\n                    <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>\n                    admission (3.7%, 5\/136) and uncontrolled underlying disease (3.7%, 5\/136). Regarding state of immunosuppression, negative outcome predictors were prolonged neutropenia (12.5%, 17\/136), corticosteroid treatment (8.1%, 11\/136) and graft\u2010vs\u2010host disease (3.7%, 5\/136). On the pathogen side, relevant predictors were galactomannan positivity (8.1%, 11\/136),\n                    <jats:italic>Aspergillus terreus<\/jats:italic>\n                    infection (2.2%, 3\/136) and lack of amphotericin B susceptibility (1.5%, 2\/136).\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    \u2010specific predictors were disseminated disease (5.1%, 7\/136) and\n                    <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>\n                    involvement (2.9%, 4\/136). Imaging results associated with negative outcome were multiple consolidations (2.9%, 4\/136), bipulmonary lesions (2.2%, 3\/136) and pleural effusion (2.2%, 3\/136). At diagnosis of\n                    <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\n                    , most frequently identified predictors of outcome were neutropenia, corticosteroid use, elevated galactomannan, renal failure and disseminated disease. The predictors may be used to identify patients at high risk for treatment failure and to stratify neglected patient groups for clinical trials.\n                  <\/jats:p>","DOI":"10.1111\/myc.12926","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T02:49:45Z","timestamp":1557283785000},"page":"651-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Baseline predictors influencing the prognosis of invasive aspergillosis in adults"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-7495","authenticated-orcid":false,"given":"Philipp","family":"Koehler","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine  Faculty of Medicine ECMM Excellence Centre for Medical Mycology University Hospital of Cologne University of Cologne Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in 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