{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:52:54Z","timestamp":1790175174189,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T00:00:00Z","timestamp":1560038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic> resistance to antifungals impaired invasive candidiasis outcome. In a context of echinocandin resistance development, we aimed to evaluate the association between phenotypic resistance to micafungin and <jats:italic>fks<\/jats:italic> mutations of <jats:italic>Candida glabrata<\/jats:italic>. For this systematic review and meta\u2010analysis, we searched MEDLINE, Scopus and Web of Science for reports published up to December 2017. Studies of <jats:italic>C\u00a0glabrata<\/jats:italic> candidiasis with minimum inhibitory concentrations (MIC) determination of micafungin and <jats:italic>fks<\/jats:italic> genotyping were included. Reviews, studies not using reference methods, non\u2010<jats:italic>glabrata Candida<\/jats:italic>, experimental isolates and undetailed mutations were excluded. Two authors independently assessed the eligibility of articles and extracted data. The main outcome was the diagnostic accuracy of <jats:italic>fks<\/jats:italic> mutations compared to micafungin MIC for <jats:italic>C\u00a0glabrata<\/jats:italic>, measured as fixed\u2010effect odd ratio. Heterogeneity was calculated with the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic. This study is registered with PROSPERO (CRD42018082023). Twenty\u2010four studies were included in the meta\u2010analysis. Pooled analysis found that S663P (OR 7.25, 95% CI 3.50\u201015.00; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001), S629P (OR 3.70, 1.64\u20108.33; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and F659del (OR 5.66, 1.22\u201026.18; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) were associated with increased risk of having a resistant isolate according to authors' interpretation of MICs. In sensitivity analysis based on new CLSI clinical breakpoints, the ORs for S663P and S629P remained significant. Genotyping of isolates of <jats:italic>C\u00a0glabrata<\/jats:italic> for S663P and S629P mutations is an effective alternative to micafungin susceptibility tests. Relevant molecular markers of drug resistance will significantly improve the management of <jats:italic>C\u00a0glabrata<\/jats:italic> infections.<\/jats:p>","DOI":"10.1111\/myc.12929","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T19:33:08Z","timestamp":1557603188000},"page":"835-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of <i>fks<\/i> gene mutations and minimum inhibitory concentrations for the detection of <i>Candida glabrata<\/i> resistance to micafungin: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-1851","authenticated-orcid":false,"given":"Anne\u2010Lise","family":"Bienvenu","sequence":"first","affiliation":[{"name":"Groupement Hospitalier Nord, Service Pharmacie Hospices Civils de Lyon Lyon France"},{"name":"ICBMS CNRS 5246, SMITh, Malaria Research Unit 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