{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:04Z","timestamp":1747187104105,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004172","name":"Mersin \u00dcniversitesi","doi-asserted-by":"publisher","award":["Project no. 2018\u20102\u2010AP\u20102952."],"award-info":[{"award-number":["Project no. 2018\u20102\u2010AP\u20102952."]}],"id":[{"id":"10.13039\/501100004172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The sexual cycle of <jats:italic>Candida glabrata<\/jats:italic> is not known; however, genomic evidence is indicative of recombination among subpopulations and the genome harbours genes necessary for undergoing mating and meiosis, which may increase fitness. The relationship between specific mating type\u2010like (<jats:italic>MTL<\/jats:italic>) loci and antifungal susceptibility is not well understood in <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>glabrata<\/jats:italic>. We investigated different combinations of clinical <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>glabrata<\/jats:italic> isolate mating types and their antifungal susceptibility profiles. Allele profiles of the mating genes of 103 clinical <jats:italic>C<\/jats:italic>.<jats:italic>\u00a0glabrata<\/jats:italic> isolates were identified, and their antifungal susceptibility to azoles, echinocandins and amphotericin B were compared. The majority (88.3%) of screened isolates harboured the <jats:bold>a<\/jats:bold> allele in the locus. The <jats:italic>MTL1<\/jats:italic>,<jats:italic> MTL2<\/jats:italic> and <jats:italic>MTL3<\/jats:italic> loci harboured <jats:bold>a<\/jats:bold> (88.3%), <jats:bold>a<\/jats:bold> (95.1%), and \u03b1 (71.8%) alleles, respectively. The <jats:italic>C<\/jats:italic>.<jats:italic>\u00a0glabrata<\/jats:italic> isolates were susceptible to echinocandins but displayed high minimal inhibitory concentrations (MICs) for azoles. The MIC ranges and MIC90 values of all isolates were 1.0 to \u226564 and 8.0\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for fluconazole, 0.06 to \u226516.0 and 0.5\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for voriconazole, 0.06 to \u226516.0 and 1.0\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for posaconazole, \u22640.015 to 0.06, and 0.03\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for caspofungin, \u22640.015 to 0.06 and 0.015\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for anidulafungin and 0.5\u20102 and 2.0\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for amphotericin B, respectively. The mating gene alleles of the clinical <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>glabrata<\/jats:italic> isolates were not associated with differences in the MICs of the tested antifungals, except for the <jats:italic>MTL3<\/jats:italic> \u03b1\u2010allele and echinocandins. The mating genotypes of the clinical <jats:italic>C<\/jats:italic>.<jats:italic>\u00a0glabrata<\/jats:italic> isolates had no recognisable common effect on antifungal susceptibility.<\/jats:p>","DOI":"10.1111\/myc.12945","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T08:23:14Z","timestamp":1559031794000},"page":"796-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mating genotypes and susceptibility profiles of clinical isolates of <i>Candida glabrata<\/i> from Turkey"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-717X","authenticated-orcid":false,"given":"Engin","family":"Kaplan","sequence":"first","affiliation":[{"name":"Advanced Technology Education, Research, and Application Center Mersin University Mersin Turkey"},{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy University of Zonguldak B\u00fclent Ecevit Zonguldak Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-4152","authenticated-orcid":false,"given":"Deniz","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy University of Mersin Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran","family":"\u00d6nder","sequence":"additional","affiliation":[{"name":"Department of Microbiology Division of Mycology Faculty of Medicine University of Eskisehir Osmangazi Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-0058","authenticated-orcid":false,"given":"Banu","family":"Metin","sequence":"additional","affiliation":[{"name":"Department of Food Engineering Faculty of Engineering and Natural Sciences Istanbul Sabahattin Zaim University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-306X","authenticated-orcid":false,"given":"Aylin","family":"D\u00f6\u011fen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy University of Mersin Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-7644","authenticated-orcid":false,"given":"Yasemin","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Microbiology Division of Mycology Faculty of Medicine University of Eskisehir Osmangazi Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-4182","authenticated-orcid":false,"given":"Macit","family":"Ilkit","sequence":"additional","affiliation":[{"name":"Department of Microbiology Division of Mycology Faculty of Medicine University of \u00c7ukurova Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00278.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12816"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2009-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12380"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12831"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02503-18"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2011.140685"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02579"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-623"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.11.027"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.2.2.328-340.2003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-2-r10"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/342749a0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.134577"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2013.09.016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00456-07"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00129-10"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.09.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02740-18"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060110"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v6.22993"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2014.12.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2000.00659.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000500019"},{"key":"e_1_2_8_28_1","first-page":"315","volume-title":"PCR Protocols: A Guide to Methods and Applications","author":"White TJ","year":"1990"},{"key":"e_1_2_8_29_1","unstructured":"CLSI.Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard 3rd ed. CLSI document M27\u2013A3.Wayne PA:Clinical and Laboratory Standards Institute;2008."},{"key":"e_1_2_8_30_1","unstructured":"CLSI.Reference method for broth dilution antifungal susceptibility testing of yeasts; Fourth Informational Supplement. CLSI document M27\u2013S4.Wayne PA:Clinical and Laboratory Standards Institute;2012."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00937-12"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00215-08"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000111"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02363-09"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1139-z"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1217-2"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02038"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fow082"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140990"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-018-0867-z"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2014.07.008"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701885636"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1567-1364.12179"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36157"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.12945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.12945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:38:10Z","timestamp":1694273890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,10]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/myc.12945"],"URL":"https:\/\/doi.org\/10.1111\/myc.12945","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2019,7,10]]},"assertion":[{"value":"2019-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}