{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:09:03Z","timestamp":1791274143004,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Vulvovaginal candidiasis (\n                    <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                    ) is a common infection of the genital tract affecting millions of women worldwide. Data on epidemiological trends of\n                    <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                    in Greece are scarce. This study was undertaken to evaluate the prevalence of\n                    <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                    among symptomatic women in Crete, Greece, identify the\n                    <jats:italic>Candida<\/jats:italic>\n                    species involved and determine their susceptibility to antifungals. Over a 6\u2010year period (2012\u20102017), 10\u00a0256 symptomatic women with vaginitis were evaluated. Isolation of yeasts was performed on Sabouraud dextrose agar with chloramphenicol, and the isolates were identified using the\n                    <jats:styled-content style=\"fixed-case\">API<\/jats:styled-content>\n                    20 C\n                    <jats:styled-content style=\"fixed-case\">AUX<\/jats:styled-content>\n                    and\/or the Vitek 2\n                    <jats:styled-content style=\"fixed-case\">YST<\/jats:styled-content>\n                    card. Susceptibility of the isolates to amphotericin, fluconazole, voriconazole and flucytosine was determined by the Vitek 2 automated system. The results were interpreted according to Clinical and Laboratory Standards criteria. Vaginal swab cultures of 1217 (11.9%) women yielded\n                    <jats:italic>Candida<\/jats:italic>\n                    species. Recurrent\n                    <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                    was documented in 62 (5.1%) of them.\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    was the most frequently isolated species (75.6%), followed by\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    (13.6%). Overall, resistance rates to amphotericin B, fluconazole, voriconazole and flucytosine were 0.2%, 6.6%, 1.4% and 2.1%, respectively. Fluconazole resistance of\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    significantly increased in the second period of the study (2015\u20102017) (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.031). This study demonstrated that\n                    <jats:styled-content style=\"fixed-case\">VVC<\/jats:styled-content>\n                    is a common infection among women in our region, with\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    being the predominant species involved. Although resistance to antifungals was infrequent, resistance to fluconazole among\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    isolates was found to significantly increase with time. Continued surveillance of changes in species distribution and susceptibility to antifungals are necessary to guide treatment.\n                  <\/jats:p>","DOI":"10.1111\/myc.12946","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T09:45:05Z","timestamp":1558950305000},"page":"692-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Epidemiology and antifungal susceptibility patterns of\n                    <i>Candida<\/i>\n                    isolates from Greek women with vulvovaginal candidiasis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0945-1732","authenticated-orcid":false,"given":"Sofia","family":"Maraki","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis University Hospital of Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria Eirini","family":"Mavromanolaki","sequence":"additional","affiliation":[{"name":"University of Crete Medical School Heraklion, Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Stafylaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis University Hospital of Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Nioti","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis University Hospital of Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hamilos","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis University Hospital of Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kasimati","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Microbial Pathogenesis University Hospital of Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02842.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032009000600006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-016-5514-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18502\/cmm.4.1.27"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)80001-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2155-2162.2005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.09.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01759-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125897"},{"key":"e_1_2_8_12_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; 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