{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:03:11Z","timestamp":1759482191161,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Summary<\/jats:title>The cut\u2010offs for total and specific IgE used for diagnosing ABPA<\/jats:styled-content> in children have been adopted from adult literature and have not been validated in the paediatric population. To establish the ideal cut\u2010offs of total IgE and Aspergillus<\/jats:italic>\u2010specific IgE for the diagnosis of ABPA<\/jats:styled-content> in children. This study was a prospective observational case\u2010control study, conducted in a tertiary care hospital in North India, enrolling 140 children with partly controlled and uncontrolled asthma. Seventy children had ABPA<\/jats:styled-content> based on the Rosenberg\u2010Patterson Criteria (Cases) whereas 70 children were without ABPA<\/jats:styled-content> (Controls). All children were subjected to clinical examination and investigations such as absolute eosinophil count, total IgE, Aspergillus<\/jats:italic>\u2010specific IgE, Aspergillus<\/jats:italic> skin prick test and radiological tests. ROC<\/jats:styled-content> curve analysis was done to determine the ideal cut\u2010offs of total and specific IgE to diagnose ABPA<\/jats:styled-content>. The ROC<\/jats:styled-content> curve analysis determined 1204IU<\/jats:styled-content>\/L as the cut\u2010off value of total IgE with a sensitivity of 79.7% (95%CI<\/jats:styled-content> 68.31% to 88.44%) and specificity of 53.1% (95%CI<\/jats:styled-content> 40.23 to 65.7). The ROC<\/jats:styled-content> analysis of specific IgE levels of children with ABPA<\/jats:styled-content> determined the cut\u2010off value of 0.49 KAU<\/jats:styled-content>\/L with a sensitivity of 94.03% (95%CI<\/jats:styled-content> 85.41 to 98.35) and specificity of 88.89% (95%CI<\/jats:styled-content> 75.94% to 96.29%). We propose that the cut\u2010offs of total and specific IgE need to be relooked in the paediatric population. Cut\u2010offs of total IgE as 1204 IU<\/jats:styled-content>\/L and for Aspergillus<\/jats:italic>\u2010specific IgE as 0.49KAU<\/jats:styled-content>\/L seem appropriate. Large multicentric studies should be conducted to determine the ideal values for diagnosing paediatric ABPA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/myc.12949","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T14:23:49Z","timestamp":1559399029000},"page":"761-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Need to re\u2010look cut\u2010off of Aspergillus<\/i>\u2010specific IgE levels in children with ABPA<\/scp>"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-1708","authenticated-orcid":false,"given":"Manvi","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Microbiology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2646-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0122"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-4-405"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1249853"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232524"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.4.282"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2017.7.3.148"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12214"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12930"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061105"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.12949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.12949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:37:55Z","timestamp":1694273875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.12949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/myc.12949"],"URL":"https:\/\/doi.org\/10.1111\/myc.12949","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}