{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:12:43Z","timestamp":1781579563981,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to describe the characteristics of patients with chronic pulmonary aspergillosis (<jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content>) in a tertiary care centre in Spain. Retrospective cohort study of all patients diagnosed with <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> between January 2010 and December 2015. The patients were identified through the Microbiology Registry. Demographic, clinical, laboratory, radiological, microbiological and clinical data were recorded. Patients were followed up for 12\u00a0months. Fifty\u2010three patients were included; median age was 61.5\u00a0years. Forty\u2010seven had a lung condition, 25 suffered from <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, 19 an active malignancy, 10 had previous pulmonary tuberculosis and 9 lung interstitial disease. Twenty\u2010eight patients presented with chronic cavitary pulmonary form (<jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content>) and 20 with subacute invasive aspergillosis (<jats:styled-content style=\"fixed-case\">SAIA<\/jats:styled-content>). Species identified were <jats:italic>A\u00a0fumigatus<\/jats:italic> (34), <jats:italic>A\u00a0niger<\/jats:italic> (5), <jats:italic>A\u00a0terreus<\/jats:italic> (4) and <jats:italic>A\u00a0flavus<\/jats:italic> (3). All\u2010cause 1\u2010year mortality was 56%. Predictors of mortality were cancer history (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 9.5; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.54\u201035.51; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and <jats:styled-content style=\"fixed-case\">SAIA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 5.49; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.49\u201019.82; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Previous pulmonary tuberculosis, surgery for the treatment of <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content> were found to be associated with lower mortality (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.05; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, &lt;0.01\u20100.47; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 0.16; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.03\u20100.88; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.2, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.01\u20100.67; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01, respectively). This is the first study providing an overview of the features of <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> in patients from Spain. <jats:styled-content style=\"fixed-case\">CCPA<\/jats:styled-content> was the most frequent form of <jats:styled-content style=\"fixed-case\">CPA<\/jats:styled-content> and <jats:italic>A\u00a0fumigatus<\/jats:italic> the most frequently isolated species. Patients with cancer history and <jats:styled-content style=\"fixed-case\">SAIA<\/jats:styled-content> had a worse prognosis.<\/jats:p>","DOI":"10.1111\/myc.12950","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T12:02:10Z","timestamp":1559649730000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic pulmonary aspergillosis in a tertiary care centre in Spain: A retrospective, observational study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-1950","authenticated-orcid":false,"given":"Juan","family":"Aguilar\u2010Company","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Oncology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Goterris\u2010Bonet","sequence":"additional","affiliation":[{"name":"Microbiology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Martinez\u2010Marti","sequence":"additional","affiliation":[{"name":"Oncology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Sampol","sequence":"additional","affiliation":[{"name":"Pneumology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito","family":"Almirante","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ruiz\u2010Camps","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054810"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.07.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2015.01.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120370"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.03.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/376526"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0322-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.08.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489474"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01062-2016"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2441"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.11.003"},{"key":"e_1_2_7_17_1","first-page":"280","article-title":"A CPAnet consensus statement on research priorities for chronic pulmonary aspergillosis: a neglected fungal infection that requires attention","volume":"2017","author":"Godet C","year":"2017","journal-title":"J Antimicrob 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