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Serum levels of periostin were analysed by enzyme\u2010linked immunosorbent assay. Serum total IgE and <jats:italic>Aspergillus fumigatus<\/jats:italic> specific IgE, IgG were measured by ImmunoCAP. Levels of cytokines (IFN\u2010\u03b3, IL\u20104, IL\u20105, IL\u20108, IL\u201010, IL\u201013 and IL\u201017A) were measured by Meso Scale Discovery (MSD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum levels of periostin in ABPA patients (85.55\u00a0ng\/mL, [68.28\u2010166] ng\/mL) were higher than those in SAFS (50.99\u00a0ng\/mL, [32.02\u201071.80] ng\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Among the analysed cytokines, IL\u20105 levels in ABPA (1.55\u00a0pg\/mL, [0.96\u20103.33] pg\/mL) were higher than those in SAFS (0.31\u00a0pg\/mL, [0.26\u20100.56] pg\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) or SAwFS (0.34\u00a0pg\/mL, [0.21\u20100.56] pg\/mL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Serum periostin levels was positively associated with total IgE levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.319, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), serum IL\u20105 levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.484, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and blood eosinophil counts (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.428, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In ROC analysis, the clinical reference value of periostin was 68.8\u00a0ng\/mL for differential diagnosis of ABPA and SAFS, with the area under the curve (AUC) of 0.81. Longitudinally, serum periostin levels did not change significantly after treatment in ABPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggested that serum levels of periostin were up\u2010regulated in ABPA patients, which may be associated with eosinophilic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12957","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T13:49:18Z","timestamp":1559915358000},"page":"780-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Elevated serum levels of periostin in patients with allergic bronchopulmonary aspergillosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Ge","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Meng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital Jinan University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2486-7931","authenticated-orcid":false,"given":"Xiaohua Douglas","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences 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