{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:12:18Z","timestamp":1790467938162,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Saprochaete clavata<\/jats:italic> is a rare cause of fungaemia with deep organ involvement in patients with haematological malignancies with reported mortality rates of 60%\u201080%. We describe four cases of <jats:italic>S\u00a0clavata<\/jats:italic> infection in a haematology unit over several months that were treated with voriconazole\u2010based regimens. We also review the literature on factors that could contribute to earlier recognition and effective treatment of <jats:italic>S\u00a0clavata<\/jats:italic>. We included all cases of culture\u2010positive <jats:italic>S\u00a0clavata<\/jats:italic> from sterile sites with associated signs of infection in patients undergoing treatment for a haematological malignancy. Isolates were identified by <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content>, and spectrum profiles were used to prepare clustering analysis of isolates. Susceptibility testing was performed using a commercial microtitre methods. <jats:italic>Saprochaete clavata<\/jats:italic> was isolated from the bloodstream in three cases and bronchial alveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) fluid in one case. Clustering analysis suggested strains of <jats:italic>S\u00a0clavata<\/jats:italic> were clonal without evidence of divergence although a common source was not identified. Susceptibility testing yielded elevated <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s to fluconazole (8\u00a0mg\/L) and echinocandins (&gt;1\u20108\u00a0mg\/L). All patients were treated with voriconazole\u2010based regimens resulting in survival of 3\/4 patients, who continued chemotherapy for their underlying malignancy without evidence of relapse. <jats:italic>Saprochaete clavata<\/jats:italic> is a rare but aggressive cause of breakthrough yeast infection in patients undergoing treatment for haematological malignancies, particularly patients with a prior history of echinocandin treatment. Timely initiation of appropriate treatment, aided by more rapid identification in microbiology laboratory, can reduce the risk of deep organ dissemination and patient death.<\/jats:p>","DOI":"10.1111\/myc.12978","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T14:39:18Z","timestamp":1564583958000},"page":"1100-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Saprochaete clavata<\/i> infections in patients undergoing treatment for haematological malignancies: A report of a monocentric outbreak and review of the literature"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1569-3447","authenticated-orcid":false,"given":"Marta","family":"Stanzani","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Ser\u00e0gnoli Institute of Hematology and Clinical Oncology S.Orsola\u2010Malpighi Hospital University of 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