{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:52:42Z","timestamp":1764172362664,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Culture\u2010based diagnosis of candidaemia suffers poor sensitivity and prolonged turnaround time. The 1,3\u2010beta\u2010D\u2010glucan (BDG) assay is a non\u2010culture\u2010based broad fungal antigen with rapid turnaround time. To assess overall, species\u2010specific and population\u2010specific sensitivity of the <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> assay for candidaemia, to determine if the <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> assay is able to detect candidaemia prior to blood culture collection, and to evaluate the performance of the assay for the detection of <jats:italic>Candida auris<\/jats:italic> candidaemia. A retrospective review of all blood cultures (<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>) with <jats:italic>C\u00a0albicans<\/jats:italic>,<jats:italic> C\u00a0parapsilosis<\/jats:italic>,<jats:italic> C\u00a0glabrata<\/jats:italic>,<jats:italic> C\u00a0krusei<\/jats:italic> and <jats:italic>C\u00a0auris<\/jats:italic> was performed. A corresponding BDG result (Fungitell<jats:sup>\u00ae<\/jats:sup>) within 10\u00a0days of the <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> was sought on the laboratory information system. Overall sensitivity of the assay was 79% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 73\u201085; 173\/218). Per species sensitivity was 81% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 72\u201090; 66\/81) for <jats:italic>C\u00a0albicans<\/jats:italic>, 72% (61\u201083; 60\/83) for <jats:italic>C\u00a0parapsilosis<\/jats:italic>, 90% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 79\u2010100; 27\/30) for <jats:italic>C\u00a0glabrata<\/jats:italic>, 71% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 43\u201099; 10\/14) <jats:italic>C\u00a0auris<\/jats:italic> and 100% (10\/10) for <jats:italic>C\u00a0krusei<\/jats:italic>. No statistically significant difference in sensitivity between species was noted (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.093). The assay demonstrated 92% (59\/64) sensitivity in neonatal <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.047) compared to 94% (15\/16) in surgery, 81% (59\/73) in adult <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>s and 71% (15\/21) in Oncology. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> results were positive up to 10\u00a0days prior to blood culture collection with no significant difference in detection rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.563). <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> results were positive up to 10\u00a0days prior to blood culture collection. <jats:styled-content style=\"fixed-case\">BDG<\/jats:styled-content> when collected a mean of 2.5\u00a0days (range 1\u201010\u00a0days) prior to blood culture collection were positive.<\/jats:p>","DOI":"10.1111\/myc.12982","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T13:29:04Z","timestamp":1565270944000},"page":"1023-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparative sensitivity of 1,3 beta\u2010D\u2010glucan for common causes of candidaemia in South Africa"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-5999","authenticated-orcid":false,"given":"Vindana","family":"Chibabhai","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases University of the Witwatersrand Johannesburg South Africa"},{"name":"Clinical Microbiology Laboratory Charlotte Maxeke Johannesburg Academic Hospital National Health Laboratory Service Johannesburg South 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