{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T21:01:04Z","timestamp":1786395664963,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An early diagnosis of chronic pulmonary aspergillosis (CPA) at the stage of simple aspergilloma (SA) remains a challenge in low\u2010 and middle\u2010income countries, where imaging may not be routinely available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigate the role of <jats:italic>Aspergillus fumigatus<\/jats:italic>\u2010specific IgG in serum, and galactomannan (GM) in bronchoalveolar lavage fluid (BALF) and serum for the diagnosis of SA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 46 consecutive treatment\u2010na\u00efve subjects with SA. The 81 controls were subjects of\u00a0treated pulmonary tuberculosis with residual radiological abnormality and minimal symptoms; and subjects with pulmonary disorders other than CPA who underwent bronchoscopy. The diagnosis of SA was based on consistent clinical features along with radiological manifestations (cavity with fungal ball).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using receiver operating characteristic (ROC) curve analysis, the best cut\u2010off value for <jats:italic>A fumigatus<\/jats:italic>\u2010specific IgG was 27.3 mgA\/L (AUROC, 0.839; sensitivity, 63.5%; specificity, 98.3%). The best cut\u2010off value for serum and BALF\u2010GM was 0.7 (AUROC, 0.636; sensitivity, 32%; specificity, 96.2%) and 2.5 (AUROC, 0.833; sensitivity, 63.7%; specificity, 97.1%), respectively. A combination of <jats:italic>A fumigatus<\/jats:italic>\u2010specific IgG (&gt;27 mgA\/L) or serum GM (\u22650.7) or BALF\u2010GM (\u22652.5) had a sensitivity and specificity of 82.6% and 96%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A combination of serological tests has the best sensitivity in diagnosing SA. More studies are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12987","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T20:52:45Z","timestamp":1565729565000},"page":"1108-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Efficiency of <i>A fumigatus<\/i>\u2010specific IgG and galactomannan testing in the diagnosis of simple aspergilloma"],"prefix":"10.1111","volume":"62","author":[{"given":"Inderpaul Singh","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahajal","family":"Dhooria","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh 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