{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:58Z","timestamp":1790283658620,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0424\u043e\u043d\u0434 \u0424\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439 (\u0420\u0424\u0424\u0418)","doi-asserted-by":"publisher","award":["18\u201034\u201000153"],"award-info":[{"award-number":["18\u201034\u201000153"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Summary<\/jats:title>The fungi Trichophyton mentagrophytes<\/jats:italic> and T\u00a0interdigitale<\/jats:italic> account for significant amount of dermatophytosis cases worldwide. These two dermatophytes form a species complex and have a number of ribosomal internal transcribed spacer (ITS) region genotypes, allowing simultaneous species identification and strain typing. Our aim was to describe the geographic distribution of T\u00a0mentagrophytes<\/jats:italic>\/T\u00a0interdigitale<\/jats:italic> ITS region genotypes and find an association between the genotypes and clinical presentations of respective infections. We performed rDNA ITS region sequencing in 397 Iranian T\u00a0mentagrophytes<\/jats:italic>\/T\u00a0interdigitale<\/jats:italic> isolates and analysed all available in GenBank entries with sequences of this kind. For the study, 515 clinical annotations were available. Statistical analysis was performed by chi\u2010squared test and Spearman rank correlation analysis. A total of 971 sequences belonged to genotypes with at least 10 geographic annotations and were classified on the basis of exclusive occurrence in a particular region or high relative contribution to a regional sample. We discerned Asian and Oceanian (\u201cKU496915<\/jats:ext-link>\u201d Type V, \u201cKT192500<\/jats:ext-link>\u201d Type VIII, \u201cKU315316<\/jats:ext-link>\u201d), European (\u201cFM986750<\/jats:ext-link>\u201d Type III, \u201cMF926358<\/jats:ext-link>\u201d Type III*, \u201cKT285210<\/jats:ext-link>\u201d Type VI) and cosmopolitan (\u201cFM986691<\/jats:ext-link>\u201d Type I, \u201cJX122216<\/jats:ext-link>\u201d Type II, \u201cKP132819<\/jats:ext-link>\u201d Type II* and \u201cAF170453<\/jats:ext-link>\u201d Type XXIV) genotypes. There was statistically significant difference in the ITS genotype distribution between different affected body sites. Trichophyton mentagrophytes<\/jats:italic> \u201cKT192500<\/jats:ext-link>\u201d Type VIII correlated with tinea cruris, T\u00a0mentagrophytes<\/jats:italic> \u201cKU496915<\/jats:ext-link>\u201d Type V correlated with tinea corporis, T\u00a0interdigitale<\/jats:italic> \u201cJX122216<\/jats:ext-link>\u201d Type II correlated with tinea pedis and onychomycosis. Trichophyton mentagrophytes<\/jats:italic> and T\u00a0interdigitale<\/jats:italic> genotypes can be associated with distinct geographic locations and particular clinical presentations.<\/jats:p>","DOI":"10.1111\/myc.12993","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T07:10:04Z","timestamp":1566630604000},"page":"1084-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Trichophyton mentagrophytes<\/i> and T\u00a0interdigitale<\/i> genotypes are associated with particular geographic areas and clinical manifestations"],"prefix":"10.1111","volume":"62","author":[{"given":"Simin","family":"Taghipour","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-3316","authenticated-orcid":false,"given":"Ivan M.","family":"Pchelin","sequence":"additional","affiliation":[{"name":"Kashkin Research Institute of Medical Mycology North\u2010Western State Medical University named after I.I. Mechnikov Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-2082","authenticated-orcid":false,"given":"Ali","family":"Zarei Mahmoudabadi","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saham","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-4378","authenticated-orcid":false,"given":"Farzad","family":"Katiraee","sequence":"additional","affiliation":[{"name":"Department of Pathobiology Faculty of Veterinary Medicine University of Tabriz Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdollah","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8436","authenticated-orcid":false,"given":"Tahereh","family":"Shokohi","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-2849","authenticated-orcid":false,"given":"Mahdi","family":"Abastabar","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1725-8433","authenticated-orcid":false,"given":"Anastasia E.","family":"Taraskina","sequence":"additional","affiliation":[{"name":"Kashkin Research Institute of Medical Mycology North\u2010Western State Medical University named after I.I. Mechnikov Saint Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoozeh","family":"Kermani","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Diba","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center School of Medicine Urmia University of Medical Sciences Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadegh","family":"Nouripour\u2010Sisakht","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Yasuj University of Medical Sciences Yasuj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0590-1073","authenticated-orcid":false,"given":"Mohammad Javad","family":"Najafzadeh","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Pakshir","sequence":"additional","affiliation":[{"name":"Basic Sciences in Infectious Diseases Research Center Parasitology & Mycology Department School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Zomorodian","sequence":"additional","affiliation":[{"name":"Basic Sciences in Infectious Diseases Research Center Parasitology & Mycology Department School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Ahmadikia","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology School of Public Health Tehran University of Medical Sciences Tehran 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