{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:39:50Z","timestamp":1789011590076,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1A09082099"],"award-info":[{"award-number":["2018R1D1A1A09082099"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2019\u20107040"],"award-info":[{"award-number":["2019\u20107040"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the accuracy of immunohistochemistry (IHC) tests for distinguishing between mucormycosis and aspergillosis and compare the clinical characteristics of mucormycosis patients according to galactomannan (GM) results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated diagnostic performance of IHC test with tissue sections of patients with culture\u2010proven invasive fungal infection. In addition, we conducted PCR assay with tissue sections of mucormycosis patients with positive GM results to evaluate the possibility of co\u2010infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In culture\u2010proven mucormycosis (n\u00a0=\u00a013) and aspergillosis (n\u00a0=\u00a020), the sensitivity and specificity of IHC test were both 100% for mucormycosis and 85% and 100%, respectively, for aspergillosis. Among the 53 patients who met the modified criteria for proven mucormycosis and had GM assay results, 24 (45%) were positive. Compared with those with negative GM results (n\u00a0=\u00a029), mucormycosis patients with positive GM results had significantly higher incidence of gastrointestinal tract infections (6\/24 [25%] vs 0\/29 [0%], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) and were more likely to be histomorphologically diagnosed as aspergillosis (7\/24 [29%] vs 2\/29 [7%], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). PCR assay amplified both <jats:italic>Aspergillus<\/jats:italic>\u2010 and <jats:italic>Mucorales<\/jats:italic>\u2010specific DNA in 6 of these 24 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunohistochemistry tests seem useful for compensating for the limitations of histomorphologic diagnosis in distinguishing between mucormycosis and aspergillosis. Some proven mucormycosis patients with positive GM results had histopathology consistent with aspergillosis and gastrointestinal mucormycosis. In addition, about one quarter of these patients revealed the evidence of co\u2010infection with aspergillosis by PCR assay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.12994","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T14:14:16Z","timestamp":1566656056000},"page":"1006-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diagnostic performance of immunohistochemistry for the aspergillosis and mucormycosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Sungim","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"},{"name":"Department of Infectious Diseases Dongguk University Ilsan Hospital Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7429-4254","authenticated-orcid":false,"given":"Joon 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Wan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Min","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Oh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul 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