{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:58:18Z","timestamp":1784606298318,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007811","name":"Sydney Medical School Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To describe the clinical features, management and outcomes in patients with fungal keratitis at the Sydney Eye Hospital, Australia, over a 9\u2010year period to guide appropriate initial therapy. A retrospective case review was conducted. Patients diagnosed with fungal keratitis from 1 January 2009 to 31 December 2017 were identified from hospital coding and pathology databases. Data were extracted from the medical records. A total of 55 episodes from 51 patients were included. Mean age was 60\u00a0\u00b1\u00a020\u00a0years (range: 19\u201091\u00a0years), and 33 were male. The fungal species was not identified in two patients. Predisposing factors included ocular surface disease in 17 eyes (32%); corneal disease, 15 (28%); corneal trauma, 12 (23%); and contact lens wear, 13 (24.5%). <jats:italic>Fusarium<\/jats:italic> spp. (15, 27%) and <jats:italic>Candida parapsilosis<\/jats:italic> (10, 18%) were the most common isolates. The median visual acuity at presentation was 1.3 logMAR (range: 0 to 3) and after treatment 0.7 logMAR (range: \u22120.02 to 3) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). Despite medical therapy, most commonly with natamycin and topical and oral voriconazole, surgical intervention was required in 21 eyes (40%); including antifungal injections in 9 (16%); corneal transplantation, 16 (30%); evisceration, 2 (4%); and enucleation, 1 (2%). A poor visual outcome was recorded in 27 of 43 (63%) patients. Fungal keratitis remains a cause of significant ocular morbidity; the majority of patients face a poor outcome despite intense medical and at times surgical treatment. In our setting, fungal keratitis was more commonly associated with corneal or ocular surface disease.<\/jats:p>","DOI":"10.1111\/myc.13009","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T08:20:34Z","timestamp":1569486034000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-1765","authenticated-orcid":false,"given":"Stephanie L.","family":"Watson","sequence":"first","affiliation":[{"name":"Save Sight Institute Discipline of Ophthalmology Sydney Medical School The University of Sydney Sydney NSW Australia"},{"name":"Sydney Eye Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-5795","authenticated-orcid":false,"given":"Maria","family":"Cabrera\u2010Aguas","sequence":"additional","affiliation":[{"name":"Save Sight Institute Discipline of Ophthalmology Sydney Medical School The University of Sydney Sydney NSW Australia"},{"name":"Sydney Eye Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-0678","authenticated-orcid":false,"given":"Lisa","family":"Keay","sequence":"additional","affiliation":[{"name":"Save Sight Institute Discipline of Ophthalmology Sydney Medical School The University of Sydney Sydney NSW Australia"},{"name":"School of Optometry University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-306X","authenticated-orcid":false,"given":"Pauline","family":"Khoo","sequence":"additional","affiliation":[{"name":"Save Sight Institute Discipline of Ophthalmology Sydney Medical School The University of Sydney Sydney NSW Australia"},{"name":"Sydney Eye Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"McCall","sequence":"additional","affiliation":[{"name":"Sydney Eye Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Lahra","sequence":"additional","affiliation":[{"name":"New South Wales Health Pathology Microbiology Randwick NSW Australia"},{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200005000-00010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01405.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.9.1070"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026462631716"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"e215","article-title":"Fungal keratitis: changing pathogens and risk factors","volume":"28","author":"Gaujoux T","year":"2011","journal-title":"Cornea"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101206010110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12306"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312881"},{"issue":"7","key":"e_1_2_8_10_1","first-page":"1035","article-title":"Visual outcome in patients of keratomycosis, at a tertiary care centre in Larkana","volume":"67","author":"Ali Shah SI","year":"2017","journal-title":"Pakistan. 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