{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:36Z","timestamp":1787015796647,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The diagnosis of invasive pulmonary aspergillosis (IPA) remains challenging. We evaluated the performance characteristics of a newly formatted\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      lateral flow test,\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD, in bronchoalveolar lavage (BAL) fluid from patients with classic risk factors for IPA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospectively banked BAL samples from 14 patients with proven or probable IPA defined by EORTC\/MSG criteria and 28 BAL samples from age\u2010matched high\u2010risk patients without IPA were tested with\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD according to manufacturer's directions. Results were read by two independent observers, and test performance was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Age, gender and underlying risk factors, except for neutropenia and haematological malignancy, were similar between IPA cases and controls. Seven patients (50%) in the IPA group received a mould\u2010active agent within 5\u00a0days prior to bronchoscopy compared with only three patients (11%) in the control group,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.004. Of 14 patients with proven\/probable IPA,\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD was positive in 3 and negative in 9; two tests yielded invalid results. All 28 control patients had a negative\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD test.\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD showed low sensitivity (25%, 95% CI: 5.5% to 57.2%), but high specificity (100%. (95% CI: 87.7% to 100%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A positive\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD test in BAL fluid of patients with classic risk factors for IPA could be useful to support the diagnosis of proven\/probable IPA because of its high specificity. However, as a stand\u2010alone test for IPA, the use of\n                      <jats:italic>Asp<\/jats:italic>\n                      LFD is limited by low sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13012","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T12:08:38Z","timestamp":1570104518000},"page":"1189-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical application of\n                    <i>Aspergillus<\/i>\n                    lateral flow device in bronchoalveolar lavage fluid of patients with classic risk factors for invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Kathleen A.","family":"Linder","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Ann Arbor MI USA"},{"name":"Infectious Diseases Section Veterans Affairs Ann Arbor Healthcare System Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Ann Arbor MI USA"},{"name":"Infectious Diseases Section Veterans Affairs Ann Arbor Healthcare System Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-0512","authenticated-orcid":false,"given":"Marisa H.","family":"Miceli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Michigan Ann Arbor MI 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