{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:11Z","timestamp":1747187111688,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Onychomycosis is a fungal infection of the nails and is one of the most common dermatological infections worldwide. Infection occurs predominantly in the nails of the feet and if left untreated patients, particularly in at\u2010risk populations, can develop more serious complications, including pain, fissuring and secondary infections. Fungal infections are also contagious and may spread to other nails or to family members. Topical treatments can be effective for mild cases of the disease and typically have fewer contraindications. However, generation of robust efficacy data for topical therapies is often hindered by the difficulties associated with monitoring progression of mild onychomycosis using the conventional methods of mycological culture to obtain confirmation of podiatrist assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to demonstrate image analysis as an effective method to monitor progression of fungal nail infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A novel digital image analysis technique was used to evaluate improvement in the visual signs of onychomycosis, when using a topical treatment kit for mild fungal nail infections in 60 participants over a 280\u2010day period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Image analysis demonstrated a significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) reduction from baseline of the affected nail area throughout the study period, results which were also perceived by the subjects themselves. Use of the treatment kit also limited the deterioration of the infection and prevented transmission to other nails.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Image analysis was established as a viable method to monitor the progression of fungal nail infections over long periods and demonstrate a clinical benefit following treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13016","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T10:40:28Z","timestamp":1570617628000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective study using image analysis to assess the efficacy of a topical treatment kit for mild onychomycosis"],"prefix":"10.1111","volume":"63","author":[{"given":"Nancy","family":"Khammo","sequence":"first","affiliation":[{"name":"Reckitt Benckiser Healthcare Ltd Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave","family":"Chesters","sequence":"additional","affiliation":[{"name":"Intertek Life Sciences Hooton Cheshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Goldstone","sequence":"additional","affiliation":[{"name":"Intertek Life Sciences Hooton Cheshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayle","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Healthcare Ltd Slough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-4104","authenticated-orcid":false,"given":"Carolyn","family":"Buckley","sequence":"additional","affiliation":[{"name":"Reckitt Benckiser Healthcare Ltd Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2014008464"},{"key":"e_1_2_9_3_1","first-page":"1186","article-title":"Clinical evaluation of safety and efficacy of a new topical treatment for onychomycosis","volume":"10","author":"Nasir A","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_4_1","first-page":"762","article-title":"Onychomycosis: Current trends in diagnosis and treatment","volume":"88","author":"Westerberg DP","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2031"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01618.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2009.01107.x"},{"key":"e_1_2_9_8_1","first-page":"426","article-title":"Transungual permeation: current insights","volume":"6","author":"Bhuptani RS","year":"2016","journal-title":"Drug Deliv Transl Res"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13358"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05242.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.267"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2014.929138"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.06.011"},{"key":"e_1_2_9_15_1","first-page":"Cd010031","article-title":"Oral antifungal medication for toenail onychomycosis","volume":"7","author":"Kreijkamp\u2010Kaspers S","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240802497218"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804878"},{"issue":"3","key":"e_1_2_9_18_1","first-page":"Cd001434","article-title":"Topical treatments for fungal infections of the skin and nails of the foot","author":"Crawford F","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_19_1","first-page":"1715","article-title":"Fungal toenail infections. BMJ","volume":"2014","author":"Ferrari J","year":"2014","journal-title":"Clin Evid"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2018.07.005"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02072-06"},{"key":"e_1_2_9_22_1","unstructured":"British Standard European.Norm International Standards Organisation. ISO 14155: 2011 \u2014 Clinical investigation of medical devices for human subjects.2011."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_9_24_1","unstructured":"European Medical Device Directive.93\/42\/EEC7 of 14 June 1993 concerning medical devices OJ L169 12.7.1993 p1. In: European Medical Device Directive ed1993."},{"key":"e_1_2_9_25_1","unstructured":"Medical Devices Regulations.(UK Legislation) Statutory Instruments 2002 No.618 Consumer protection. In:2002."},{"key":"e_1_2_9_26_1","first-page":"00","article-title":"How to treat fungal nail effectively","volume":"14","author":"Soni A","year":"2018","journal-title":"Pathophysiology"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3495"},{"key":"e_1_2_9_28_1","unstructured":"Efinaconazole 10% topical solution.Summary of Product Characteristics.2016; Available at:https:\/\/www.bauschhealth.com\/Portals\/25\/Pdf\/PI\/Jublia-PI.pdf. Accessed December 2018."},{"key":"e_1_2_9_29_1","unstructured":"Trosyl Nail Solution.Summary of Product Characteristics.2013; Available at:https:\/\/www.medicines.org.uk\/emc\/product\/1071\/smpc. Accessed December 2018."}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:44:16Z","timestamp":1694076256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/myc.13016"],"URL":"https:\/\/doi.org\/10.1111\/myc.13016","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2019,12,17]]},"assertion":[{"value":"2019-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}