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Although immune responses play crucial roles in controlling the fate of fungal infections, immunocompromised patients are at high risk with high mortality. Tuning the immune response against fungal infections might be an effective strategy for controlling and reducing the pathological damages. MicroRNAs (miRNAs) are known as the master regulators of immune response. These single\u2010stranded tuners (18\u201023 bp non\u2010coding RNAs) are endogenously expressed by all metazoan eukaryotes and have emerged as the master gene expression controllers of at least 30% human genes. In this review article, following the review of biology and physiology (biogenesis and mechanism of actions) of miRNAs and immune response against fungal infections, the interactions between them were scrutinised. In conclusion, miRNAs might be considered as one of the potential goals in immunotherapy for fungal infections. Undoubtedly, advanced studies in this field, further identifying of miRNA roles in governing the immune response, pave the way for inclusion of miRNA\u2010related immunotherapeutic in the treatment of life\u2010threatening fungal infections.<\/jats:p>","DOI":"10.1111\/myc.13017","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T23:58:49Z","timestamp":1570665529000},"page":"4-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interactions between immune response to fungal infection and microRNAs: The pioneer tuners"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-4690","authenticated-orcid":false,"given":"Keyvan","family":"Pakshir","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology School of Medicine Shiraz University of Medical Sciences Shiraz 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