{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:23:34Z","timestamp":1784013814564,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Time to positivity (TTP) and differential time to positivity (DTTP) between central and peripheral blood cultures are commonly used for bacteraemia to evaluate the likelihood of central venous catheter (CVC)\u2010related bloodstream infection. Few studies have addressed these approaches to yeast fungaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate TTP and DTTP to assess CVC\u2010related yeast fungaemia (CVC\u2010RYF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>We retrospectively analysed the results from 105 adult patients with incident fungaemia, with CVC removed and cultured, collected from 2010 to 2017. The bottles were incubated in a BioM\u00e9rieux BacT\/ALERT 3D and kept for at least 5\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 105 patients included, most were oncology patients (85.7%) and had of long\u2010term CVC (79.6%); 32 (30.5%) had a culture\u2010positive CVC (defined as CVC\u2010RYF) with the same species as in blood culture, and 69.5% had culture\u2010negative CVC (defined as non\u2010CVC\u2010RYF, NCVC\u2010RYF). <jats:italic>Candida albicans<\/jats:italic> represented 46% of the episodes. The median TTP was statistically different between CVC\u2010RYF and NCVC\u2010RYF (16.8\u00a0hours interquartile range (IQR) [9.7\u201028.6] vs 29.4\u00a0hours [IQR 20.7\u201041.3]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). A TTP &lt;10\u00a0hours had the best positive likelihood ratio (21.5) for CVC\u2010RYF, although the sensitivity was only 28%. DTTP was available for 52 patients. A DTTP &gt;5\u00a0hours had a sensitivity of 100% and a specificity of 71% for CVC\u2010RYF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since the median TTP was 17\u00a0hours and the most performing DTTP &gt;5\u00a0hours, these delays are too long to take a decision in the same operational day. More rapid methods for detecting infected catheters should be tested to avoid unnecessary CVC withdrawal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13024","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T04:59:54Z","timestamp":1571547594000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Time to and differential time to blood culture positivity for assessing catheter\u2010related yeast fungaemia: A longitudinal, 7\u2010year study in a single university hospital"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0470-6866","authenticated-orcid":false,"given":"Maud","family":"Gits\u2010Muselli","sequence":"first","affiliation":[{"name":"Parasitology\u2010Mycology Laboratory Lariboisi\u00e8re Saint\u2010Louis Fernand Widal Hospital Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris 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