{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:27:58Z","timestamp":1790141278095,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Onychomycosis affects almost 6% of the world population. Topical azoles and systemic antifungal agents are of low efficacy and can have undesirable side effects. An effective, non\u2010invasive therapy for onychomycosis is an unmet clinical need.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine the efficacy threshold of non\u2010thermal atmospheric plasma (NTAP) to treat onychomycosis in an in vitro model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A novel toe\/nail\u2010plate model using cadaver nails and agarose media inoculated with <jats:italic>Candida albicans<\/jats:italic> was exposed to a range of NTAP doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Direct exposure of <jats:italic>C\u00a0albicans<\/jats:italic> and <jats:italic>Trichophyton mentagrophytes<\/jats:italic> to 12\u00a0minutes of NTAP results in complete killing at doses of 39 and 15\u00a0kPulses, respectively. Onset of reduced viability of <jats:italic>C albicans<\/jats:italic> to NTAP treatment through the nail plate occurs at 64\u00a0kPulses with 10\u00d7 and 100\u00d7 reduction at 212 and 550\u00a0kPulses, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NTAP is an effective, non\u2010invasive therapeutic approach to onychomycosis that should be evaluated in a clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13030","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T01:04:45Z","timestamp":1572656685000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Non\u2010thermal atmospheric plasma treatment of onychomycosis in an in vitro human nail model"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-2571","authenticated-orcid":false,"given":"Jeffry 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