{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:55:11Z","timestamp":1792641311041,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["098\/2012"],"award-info":[{"award-number":["098\/2012"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cryptococcal meningitis is a several disease common in late stage of HIV infection. Detection of cryptococcal antigen (CrAg) is an important for early diagnosis of this invasive mycosis. The pre\u2010emptive treatment for isolated antigenemia prevents the onset of meningoencephalitis. Screening CrAg in patients with low CD4 count is cost\u2010effective in countries with prevalence of antigenemia above 3%. However, in Brazil, the number of prevalence studies on cryptococcosis and HIV is insufficient. The objective of this study is to estimate the prevalence of CrAg and describe clinical characteristics from a cohort of patients followed at a reference center in Brazil. CrAg screening was performed in 89 inpatients with CD4 count \u2264200 cells\/mm<jats:sup>3<\/jats:sup> or WHO stage III\/IV from the National Institute of Infecttious Disease, Rio de Janeiro. Patients with isolated antigenemia received pre\u2010emptive therapy with fluconazole and patients with meningoencephalitis were treated with Amphotericin B. Individuals were followed up for 12 months. Prevalence of serum CrAg was 11.23%, cryptococcal meningoencephalitis 6.74% and isolated antigenemia 4.81%. None of the patients with isolated antigenemia developed meningoencephalitis during the follow up. Signs and symptoms of meningoencephalitis were unspecific or absent. Our study suggests the need of CrAg screening in Brazil and highlights that lumbar puncture is mandatory in all individuals CrAg positive to exclude asymptomatic meningoencephalitis.<\/jats:p>","DOI":"10.1111\/myc.13032","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T20:29:51Z","timestamp":1573590591000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cryptococcal antigenemia prevalence and clinical data in HIV\u2010infected patients from the reference centre at INI\u2010FIOCRUZ, Rio de Janeiro, Southeast of Brazil"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7595-7363","authenticated-orcid":false,"given":"Marcela de F.","family":"Ferreira","sequence":"first","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Brito\u2010Santos","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Trilles","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A.","family":"Almeida","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Wanke","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdilea G.","family":"Veloso","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estevao P.","family":"Nunes","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia dos S.","family":"Lazera","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Disease Evandro Chagas (INI) FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30243-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.4.515"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282a4a64d"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu094"},{"key":"e_1_2_8_7_1","unstructured":"World Health Organization.WHO | Rapid advice: Diagnosis prevention and management of cryptococcal disease in HIV\u2010infected adults adolescents and children. WHO.http:\/\/www.who.int\/hiv\/pub\/cryptococcal_disease2011\/en\/. Published2011. 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