{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:58:54Z","timestamp":1765976334869,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lanoconazole (LCZ) is a topical antifungal agent clinically used to treat fungal infections such as tinea pedis. LCZ has not only antifungal effects but also anti\u2010inflammatory effects, which have the potential to provide additional clinical benefits. However, the characteristic features of the inhibitory effects of LCZ on skin inflammation remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated the inhibitory effects of topical application of LCZ, and compared the effects of LCZ with those of other antifungal agents including liranaftate, terbinafine and amorolfine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each antifungal agent was topically applied on 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoylphorbol\u201013\u2010acetate\u2010induced irritant dermatitis and 2,4,6\u2010trinitrophenyl chloride\u2010induced contact dermatitis in mice (BALB\/c). The ear thickness, myeloperoxidase activity and inflammatory mediator contents were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LCZ dose\u2010dependently suppressed 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoylphorbol\u201013\u2010acetate\u2010induced irritant dermatitis, suppressed the production of neutrophil chemotactic factors such as keratinocyte\u2010derived chemokine and macrophage inflammatory protein\u20102, and inhibited neutrophil infiltration to the inflammation site. Moreover, 1% LCZ reduced the ear swelling in mice with 2,4,6\u2010trinitrophenyl chloride\u2010induced contact dermatitis in accordance with the inhibition of interferon\u2010\u03b3 production. The inhibitory potency of LCZ on these types of dermatitis in mice was stronger than that of other types of antifungal agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010inflammatory effects of LCZ were exerted through the inhibition of inflammatory mediator production. These effects may contribute to the relief of dermatitis symptoms in patients with tinea pedis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13034","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T09:19:51Z","timestamp":1573723191000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti\u2010inflammatory effect of lanoconazole on 12\u2010<i>O<\/i>\u2010tetradecanoylphorbol\u201013\u2010acetate\u2010 and 2,4,6\u2010trinitrophenyl chloride\u2013induced skin inflammation in mice"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-1507","authenticated-orcid":false,"given":"Aki","family":"Nakamura","sequence":"first","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-0474","authenticated-orcid":false,"given":"Hideya","family":"Uratsuji","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4370-7594","authenticated-orcid":false,"given":"Yoshihito","family":"Yamada","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-1227","authenticated-orcid":false,"given":"Kei","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-1772","authenticated-orcid":false,"given":"Naoki","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-3789","authenticated-orcid":false,"given":"Tatsumi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories Maruho Co., Ltd. Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2095","article-title":"Topical treatment of common superficial tinea infections","volume":"65","author":"Weinstein A","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_3_1","first-page":"CD003584","article-title":"Oral treatments for fungal infections of the skin of the foot","author":"Bell\u2010Syer SE","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.47.103"},{"key":"e_1_2_7_5_1","first-page":"935","article-title":"Interleukin\u20108 and tumor necrosis factor alpha production in human epidermal keratinocytes induced by Trichophyton mentagrophytes","volume":"9","author":"Nakamura Y","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0780-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1993.tb01315.x"},{"key":"e_1_2_7_8_1","first-page":"87","article-title":"Interferon\u2010\u03b3 production in peripheral lymphocytes of patients with tinea pedis: comparison of patients with and without tinea unguium","volume":"39","author":"Koga T","year":"2001","journal-title":"Med Mycol"},{"key":"e_1_2_7_9_1","first-page":"5","article-title":"[The pathophysiology and defense mechanism against superficial and subcutaneous fungal infection]. 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