{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:49:34Z","timestamp":1788918574864,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special","doi-asserted-by":"publisher","award":["CN, 2016\u20101\u20105015"],"award-info":[{"award-number":["CN, 2016\u20101\u20105015"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the diagnostic value of serum <jats:italic>Candida<\/jats:italic> mannan antigen (MN) and anti\u2010mannan IgG and IgM antibodies for candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective cohort study. Clinical data and venous blood samples from 23 medical centres in Beijing, China were collected between 1 January 2017 and 31 December 2018. All collected specimens were tested within one week for serum <jats:italic>Candida<\/jats:italic> MN and IgG and IgM antibodies using an ELISA kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 452 patients were enrolled, including 188 patients in the <jats:italic>Candida<\/jats:italic> exposure groups (56 patients with <jats:italic>Candida<\/jats:italic> bloodstream infection, 69 patients with <jats:italic>Candida<\/jats:italic>\u2010positive tracheal aspirate cultures and 63 patients with <jats:italic>Candida<\/jats:italic>\u2010positive urine cultures) and 264 patients in the control groups (212 healthy controls and 52 patients with bacteraemia). The receiver operating characteristic (ROC) curve of the 56 patients with <jats:italic>Candida<\/jats:italic> bloodstream infection and 212 healthy controls showed that serum MN and IgG had good diagnostic value. The area under the ROC curve (AUC) values were 0.812 (95% CI, 0.750\u20100.873) and 0.866 (95% CI, 0.808\u20100.924), respectively, wherein the MN specificity and sensitivity were 86.79% and 60.71%, and the IgG were 84.43% and 80.36%, respectively. The AUC of the combination of serum MN and IgG was 0.871(95% CI, 0.813\u20100.929), and the specificity and sensitivity were 93.87% and 57.14%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The serum levels of <jats:italic>Candida<\/jats:italic> MN and its IgG antibody have diagnostic value for <jats:italic>Candida<\/jats:italic> bloodstream infection, and combination of MN and IgG can improve diagnostic specificity and may provide a new approach for diagnosis of candidaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13035","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:39:57Z","timestamp":1574422797000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diagnostic value of <i>Candida<\/i> mannan antigen and anti\u2010mannan IgG and IgM antibodies for <i>Candida<\/i> infection"],"prefix":"10.1111","volume":"63","author":[{"given":"Kaifei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pulmonary &amp; Critical Care Medicine Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Luo","sequence":"additional","affiliation":[{"name":"Center for Clinical Laboratory Medicine PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary &amp; Critical Care Medicine Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheling","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary &amp; Critical Care Medicine Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary &amp; Critical Care Medicine Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary &amp; 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