{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:29:32Z","timestamp":1790630972243,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["HI15C2259"],"award-info":[{"award-number":["HI15C2259"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Since mould\u2010active azole prophylaxis has become a standard approach for patients with high\u2010risk haematologic diseases, the epidemiology of invasive fungal infections (IFIs) has shifted towards non\u2010\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    moulds. It was aimed to identify the epidemiology and characteristics of non\u2010\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    invasive mould infections (NAIMIs). Proven\/probable NAIMIs developed in patients with haematologic diseases were reviewed from January 2011 to August 2018 at Catholic Hematology hospital, Seoul, Korea. There were 689 patients with proven\/probable invasive mould infections; of them, 46 (47 isolates) were diagnosed with NAIMIs. Fungi of the Mucorales order (n\u00a0=\u00a027, 57.4%) were the most common causative fungi, followed by\n                    <jats:italic>Fusarium<\/jats:italic>\n                    (n\u00a0=\u00a09, 19.1%). Thirty\u2010four patients (73.9%) had neutropenia upon diagnosis of NAIMIs, and 13 (28.3%) were allogeneic stem cell transplantation recipients. The most common site of NAIMIs was the lung (n\u00a0=\u00a027, 58.7%), followed by disseminated infections (n\u00a0=\u00a08, 17.4%). There were 23.9% (n\u00a0=\u00a011) breakthrough IFIs, and 73.9% (n\u00a0=\u00a034) had co\u2010existing bacterial or viral infections. The overall mortality at 6 and 12\u00a0weeks was 30.4% and 39.1%, respectively. Breakthrough IFIs (adjusted hazards ratio [aHR]\u00a0=\u00a01.99, 95% CI: 1.3\u20104.41,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.031) and surgical treatment (aHR\u00a0=\u00a00.09, 95% CI: 0.02\u20100.45,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.003) were independently associated with 6\u2010week overall mortality. NAIMIs were not rare and occur as a complex form of infection often accompanied by breakthrough\/mixed\/concurrent IFIs and bacterial or viral infections. More active diagnostic efforts for NAIMIs are needed.\n                  <\/jats:p>","DOI":"10.1111\/myc.13038","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T02:29:49Z","timestamp":1574648989000},"page":"257-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Characteristics and risk factors for mortality of invasive non\u2010\n                    <i>Aspergillus<\/i>\n                    mould infections in patients with haematologic diseases: A single\u2010centre 7\u2010year cohort study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-8918","authenticated-orcid":false,"given":"Hyeon\u2010Jeong","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"College of Medicine Catholic Hematology Hospital The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Yeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"College of Medicine Catholic Hematology Hospital The Catholic University of Korea Seoul Korea"},{"name":"College of Medicine Vaccine Bio Research Institute The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-0641","authenticated-orcid":false,"given":"Dong\u2010Gun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea"},{"name":"College of Medicine Catholic Hematology Hospital The Catholic University of Korea Seoul Korea"},{"name":"College of Medicine Vaccine Bio Research Institute The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulmin","family":"Park","sequence":"additional","affiliation":[{"name":"College of Medicine Vaccine Bio Research Institute The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Sun","family":"Chun","sequence":"additional","affiliation":[{"name":"College of Medicine Vaccine Bio Research Institute The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2018.036"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"e_1_2_7_4_1","first-page":"3221","article-title":"European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia","volume":"73","author":"Maertens JA","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061098"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw199"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12318"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12357"},{"key":"e_1_2_7_10_1","first-page":"237","article-title":"Breakthrough invasive fungal diseases during voriconazole treatment for aspergillosis: a 5\u2010year retrospective cohort study","volume":"55","author":"Kim SB","year":"2017","journal-title":"Med Mycol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110087"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12688"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix130"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2374-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04435-14"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00318-16"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.12.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040863"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks189"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12465"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.246"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:52:16Z","timestamp":1694065936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/myc.13038"],"URL":"https:\/\/doi.org\/10.1111\/myc.13038","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,10]]},"assertion":[{"value":"2019-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}