{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:35:43Z","timestamp":1789414543183,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010albicans<jats:italic>Candida spp.<\/jats:italic>are an emerging cause of hospital\u2010acquired bloodstream infections, associated with high mortality due to the challenges in diagnosis and delayed treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate a cluster of healthcare\u2010associated invasive candidiasis caused by<jats:italic>C\u00a0tropicalis<\/jats:italic>and review the literature of healthcare\u2010associated outbreaks or clusters caused by<jats:italic>C\u00a0tropicalis<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An investigation was performed to determine clinical presentation, treatment outcomes and the factors contributing to<jats:italic>C\u00a0tropicalis<\/jats:italic>candidemia occurrence. We searched the Medline database via PubMed and Ovid using the keywords of \u201cCandida tropicalis\u201d combined with \u201coutbreak\u201d or \u201cclustering\u201d or \u201cclusters,\u201d and we limited the search to studies conducted from January 1989 to January 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report two related cases of<jats:italic>C\u00a0tropicalis<\/jats:italic>candidemia among patients with AML following a period of neutropenia, who had erythematous skin rash as a first manifesting sign of candidiasis.<jats:italic>C\u00a0tropicalis<\/jats:italic>was isolated from blood and skin cultures of both patients, which were identical by pulsed\u2010field gel electrophoresis typing. Our systematic review of outbreaks caused by<jats:italic>C\u00a0tropicalis<\/jats:italic>suggests that (a) most reported outbreaks have occurred in neonatal and adult ICUs; (b) patients who receive total parenteral therapy, antibiotics and those who have indwelling catheters and recent surgery are at high risk of infection; and (c) environmental and healthcare personnel surveillance suggest that cross\u2010contamination is a major risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Control of nosocomial outbreaks caused by<jats:italic>C\u00a0tropicalis<\/jats:italic>should include better infection control measures, education of healthcare professionals especially working in adult and neonatal intensive care and haematology units.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13048","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T07:16:22Z","timestamp":1578899782000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Investigation of a healthcare\u2010associated<i>Candida tropicalis<\/i>candidiasis cluster in a haematology unit and a systematic review of nosocomial outbreaks"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-2277","authenticated-orcid":false,"given":"Aleksandra","family":"Barac","sequence":"first","affiliation":[{"name":"Clinic for Infectious and Tropical Diseases Clinical Center of Serbia Belgrade Serbia"},{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Cevik","sequence":"additional","affiliation":[{"name":"Division of Infection 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Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Micic","sequence":"additional","affiliation":[{"name":"Clinic for Gynecology and Obstetrics Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Rubino","sequence":"additional","affiliation":[{"name":"Microbiology Unit Department of Biomedical Science University of Sassari Sassari 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