{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:03Z","timestamp":1790957703843,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candidaemia remains associated with high mortality and increased costs worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the changes over time in the relative prevalence of non\u2010albicans candidaemia (NAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review, meta\u2010analysis and meta\u2010regression were performed. Observational studies investigating the epidemiology of consecutive, non\u2010selected, candidaemia episodes were included. Two separated analyses were conducted: (a) whole hospital analysis and (b) intensive care unit (ICU) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Starting from an initial total of 7726 records, 220 studies fulfilled inclusion criteria. The pooled prevalence of NAC in whole hospital analysis was 49.5% (95% confidence intervals [CI] 48.0\u201051.1, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 93.1%), while the pooled prevalence in ICU analysis was 50.6% (95% CI 46.6\u201054.6; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> 86.7%). In meta\u2010regression, a progressive increase in NAC prevalence was observed in whole hospital analysis, although it explained only a small portion of between\u2010study variance (estimated yearly prevalence change +0.3%, 95% CI from +0.1% to +0.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> 3.42%) and was observed only in some continents in subgroup analyses. No relevant changes over time were observed in NAC prevalence for ICU studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We registered an increasing trend in the relative prevalence of NAC, which, nonetheless, seems to be limited to some continents and to contribute only minimally to explain the observed differences in NAC prevalence across studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13054","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T07:15:41Z","timestamp":1580368541000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Changes in the relative prevalence of candidaemia due to non\u2010<i>albicans Candida<\/i> species in adult in\u2010patients: A systematic review, meta\u2010analysis and meta\u2010regression"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-1759","authenticated-orcid":false,"given":"Daniele Roberto","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Clinica Malattie Infettive Ospedale Policlinico San Martino \u2013 IRCCS Genoa Italy"},{"name":"Department of Health Sciences University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7218-7762","authenticated-orcid":false,"given":"Alberto Enrico","family":"Maraolo","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-4125","authenticated-orcid":false,"given":"Vittorio","family":"Simeon","sequence":"additional","affiliation":[{"name":"Department of Public, Clinical and Preventive Medicine Medical Statistics Unit University of Campania Luigi Vanvitelli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Magn\u00e8","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive Ospedale Policlinico San Martino \u2013 IRCCS Genoa Italy"},{"name":"Department of Health Sciences University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Pace","sequence":"additional","affiliation":[{"name":"Department of Women, Child and General and Specialized Surgery University of Campania \"Luigi Vanvitelli\" Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Gentile","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases Department of Clinical Medicine and Surgery University of Naples Federico II Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-2264","authenticated-orcid":false,"given":"Paolo","family":"Chiodini","sequence":"additional","affiliation":[{"name":"Department of Public, Clinical and Preventive Medicine Medical Statistics Unit University of Campania Luigi Vanvitelli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Viscoli","sequence":"additional","affiliation":[{"name":"Clinica Malattie Infettive Ospedale Policlinico San Martino \u2013 IRCCS Genoa Italy"},{"name":"Department of Health Sciences University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Fondazione Policlinico Universitario A. 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