{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:23:32Z","timestamp":1791933812200,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["1352"],"award-info":[{"award-number":["1352"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Azole resistance in <jats:italic>Aspergillus fumigatus<\/jats:italic> is an emerging problem and reported from all continents. As triazole antifungals are the mainstay of therapy in the management of invasive aspergillosis, azole\u2010resistant <jats:italic>A\u00a0fumigatus<\/jats:italic> has become a major medical concern and with complicated clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Screening of environmental presence of azole\u2010resistant <jats:italic>A\u00a0fumigatus<\/jats:italic> in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Compost from Northern Iran, collected between 2017 and 2018, was screened for the presence of azole\u2010resistant <jats:italic>A\u00a0fumigatus<\/jats:italic> with azole\u2010containing agar. Phenotypic MICs were obtained from selected, molecularly confirmed isolates. <jats:italic>cyp51A<\/jats:italic> gene sequencing and genotyping of azole\u2010resistant isolates were done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 300 compost samples, three <jats:italic>A\u00a0fumigatus<\/jats:italic> isolates had high voriconazole MICs (\u226516\u00a0mg\/L) and harboured the TR<jats:sub>46<\/jats:sub>\/Y121F\/T289A mutation in the <jats:italic>cyp51A<\/jats:italic> gene. Microsatellite typing of these isolates showed that two strains had the same allele across all nine examined microsatellite loci and were genotypically related to Indian azole\u2010resistant strains. The other isolate had a different genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first report of <jats:italic>A\u00a0fumigatus<\/jats:italic> with TR<jats:sub>46<\/jats:sub>\/Y121F\/T289A mutation\u00a0from the region. Monitoring and surveillance of antifungal susceptibility of clinical <jats:italic>A\u00a0fumigatus<\/jats:italic> is warranted in Iran and elsewhere in the region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13064","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T07:45:15Z","timestamp":1581666315000},"page":"430-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["First azole\u2010resistant <i>Aspergillus fumigatus<\/i> isolates with the environmental TR<sub>46<\/sub>\/Y121F\/T289A mutation in Iran"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-7446","authenticated-orcid":false,"given":"Fatemeh","family":"Ahangarkani","sequence":"first","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences Sari Iran"},{"name":"Department of Medical Microbiology and Infectious Diseases Canisius\u2010Wilhelmina 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