{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:54:09Z","timestamp":1791140049587,"version":"4.1.0"},"reference-count":369,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal diseases remain a major cause of morbidity and mortality in cancer patients undergoing intensive cytotoxic therapy. The choice of the most appropriate antifungal treatment (AFT) depends on the fungal species suspected or identified, the patient's risk factors (eg length and depth of granulocytopenia) and the expected side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Since the last edition of recommendations for \u2018Treatment of invasive fungal infections in cancer patients\u2019 of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) in 2013, treatment strategies were gradually moving away from solely empirical therapy of presumed or possible invasive fungal diseases (IFDs) towards pre\u2010emptive therapy of probable IFD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The guideline was prepared by German clinical experts for infections in cancer patients in a stepwise consensus process. MEDLINE was systematically searched for English\u2010language publications from January 1975 up to September 2019 using the key terms such as \u2018invasive fungal infection\u2019 and\/or \u2018invasive fungal disease\u2019 and at least one of the following: antifungal agents, cancer, haematological malignancy, antifungal therapy, neutropenia, granulocytopenia, mycoses, aspergillosis, candidosis and mucormycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AFT of IFDs in cancer patients may include not only antifungal agents but also non\u2010pharmacologic treatment. In addition, the armamentarium of antifungals for treatment of IFDs has been broadened (eg licensing of isavuconazole). Additional antifungals are currently under investigation or in clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Here, updated recommendations for the treatment of proven or probable IFDs are given. All recommendations including the levels of evidence are summarised in tables to give the reader rapid access to key information.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13082","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T06:01:57Z","timestamp":1585720917000},"page":"653-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Treatment of invasive fungal diseases in cancer patients\u2014Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-9729","authenticated-orcid":false,"given":"Markus","family":"Ruhnke","sequence":"first","affiliation":[{"name":"Division of Haematology, Oncology and Palliative Care Department of Internal Medicine Evangelisches Klinikum Bethel Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine University of Cologne Cologne Germany"},{"name":"ECMM Excellence Centre of Medical Mycology Cologne Germany<!--Query ID=\"q4\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne Cologne Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln) University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schmidt\u2010Hieber","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr H\u00e4matologie und Onkologie Carl\u2010Thiem Klinikum Cottbus Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nael","family":"Alakel","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Haematology and Oncology University Hospital Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Boell","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Buchheidt","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Mannheim University Hospital Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Christopeit","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation &amp; 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