{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T12:04:23Z","timestamp":1772539463411,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Several studies described single nucleotide polymorphisms (SNPs) on pattern recognition receptor (PRR) such as toll\u2010like receptors (TLRs), dendritic cell\u2010associated C\u2010type lectin\u20101 (Dectin\u20101\/CLEC7A) genes of patients with invasive fungal infections (IFIs) caused by <jats:italic>Candida<\/jats:italic> and <jats:italic>Aspergillus.<\/jats:italic> We screened <jats:italic>TLR4<\/jats:italic>, <jats:italic>Dectin\u20101<\/jats:italic> and <jats:italic>PTX3<\/jats:italic> polymorphisms in a Turkish population with invasive aspergillosis (IA) underlying haematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2010control study, a cohort of 59 patients with haematological malignancies were included. There were 26 IA patients assigned by the EORTC\u2010MSG criteria and 33 patients with no evidence of fungal disease. DNA and RNA were isolated from frozen bone marrow and serum samples. RNA levels and polymorphisms of <jats:italic>TLR4<\/jats:italic> (rs4986790, rs4986791), <jats:italic>Dectin\u20101<\/jats:italic> (rs16910526, rs7309123) and <jats:italic>PTX3<\/jats:italic> (rs2305619, rs3816527) were determined. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by unconditional logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p><jats:italic>TLR4<\/jats:italic>, <jats:italic>PTX3<\/jats:italic> and <jats:italic>Dectin\u20101<\/jats:italic> genes were downregulated in aspergillosis cohort under similar haematological conditions. <jats:italic>TLR4<\/jats:italic> expression was 0.0626\u00a0\u00b1\u00a00.032 in controls when compared to IA patients as 0.0077\u00a0\u00b1\u00a00.014, and the difference was significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.026). There was a difference in also the <jats:italic>PTX3<\/jats:italic> gene among IA (0.0043\u00a0\u00b1\u00a00.004) and control (0.5265\u00a0\u00b1\u00a00.0043) groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.035). The <jats:italic>Dectin\u20101<\/jats:italic> (CLEC\/A) expression was downregulated in IA group (0.1887\u00a0\u00b1\u00a00.072 &amp; 0.0655\u00a0\u00b1\u00a00.010) but not statistically significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Conditional logistic regression analyses indicated that the GT genotype of rs16910526 polymorphism in Dectin\u20101 gene was associated with lower risk of IA (odds ratio\u00a0=\u00a03.635, 95% confidence interval\u00a0=\u00a00.690\u20103.138, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13087","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T05:39:21Z","timestamp":1586929161000},"page":"832-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retrospective analysis of the association of the expression and single nucleotide polymorphisms (SNPs) of the <i>TLR4, PTX3 and Dectin\u20101<\/i> (<i>CLEC\/A<\/i>) genes with development of invasive aspergillosis among haematopoietic stem cell transplant recipients with oncohaematological disorders"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0961-7325","authenticated-orcid":false,"given":"Ayse","family":"Kalkanci","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Tug","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isil","family":"Fidan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Guzel Tunccan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubeyde Nur","family":"Ozkurt","sequence":"additional","affiliation":[{"name":"Department of Hematology Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep Arzu","family":"Yegin","sequence":"additional","affiliation":[{"name":"Department of Hematology Gazi University School of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Ay\u00e7a","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Gazi University School of Medicine Ankara Turkey"},{"name":"Yenimahalle State Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Kuralay","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Gazi University School of Medicine Ankara Turkey"},{"name":"Palandoken State Hospital Erzurum 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