{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:21:23Z","timestamp":1787062883015,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary mucormycosis (PM) represents a serious burden in terms of morbidity and mortality in immunocompromised patients. Studies of prognostic factors in patients with PM are limited and have involved small numbers of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients diagnosed with proven and probable PM according to the modified definitions of the EORTC\/MSG 2008 in a tertiary hospital in Seoul, South Korea, between 2008 and 2019 were retrospectively enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 49 patients including 31 (63%) with proven PM and 18 (37%) with probable PM were enrolled. The 90\u2010day mortality rate was 49% (24\/49). Neutropenia, thrombocytopenia, use of voriconazole at clinical suspicion, positivity of non\u2010sterile culture, use of steroid and treatment without surgery were more common in fatal cases than non\u2010fatal cases. Voriconazole use at clinical suspicion for invasive mould pneumonia (OR 6.91,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01) and prolonged neutropenia (OR 4.86,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) were independent risk factors for mortality. Voriconazole use at clinical suspicion was associated with positive galactomannan (GM) assay (OR 5.93,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02) and history of invasive pulmonary aspergillosis (OR, 6.88,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>About half of the patients with PM died within 90\u00a0days of diagnosis, and fatal outcomes were common in patients with prolonged neutropenia and empirical voriconazole use. Caution is needed in using voriconazole even in patients with positive GM results and prior histories of invasive pulmonary aspergillosis in whom PM cannot be ruled out by differential diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13092","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T08:14:50Z","timestamp":1587197690000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk factors for mortality in patients with pulmonary mucormycosis"],"prefix":"10.1111","volume":"63","author":[{"given":"Hyo\u2010Ju","family":"Son","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"},{"name":"Division of Infectious Diseases Department of Internal Medicine Soonchunhyang University Seoul Hospital Soonchunhyang University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Seon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungim","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Dongguk University Ilsan Hospital Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul 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of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hee","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-8253","authenticated-orcid":false,"given":"Sung\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3117","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Dimitrios 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