{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:47:06Z","timestamp":1778266026454,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["2938"],"award-info":[{"award-number":["2938"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several previous studies have shown cavitary lung lesions in old pulmonary tuberculosis (PTB) increase the risk of fungus ball. Detection of galactomannan (GM) in bronchoalveolar lavage (BAL) is also proposed as a diagnostic approach for the fungus ball.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the diagnosis of fungus balls and GM levels in BAL samples in PTB patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 110 PTB patients were evaluated for fungus ball during 2017\u20102019. The patients were evaluated for radiological, histopathological results and mycological findings of BAL including GM detection and culture. The sensitivity, specificity and positive and negative predictive value for GM test were calculated. The optimal cut\u2010off for BAL GM testing was determined by receiver operating characteristic (ROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 110 PTB patients, nine (8.18%) showed fungus ball, all with old PTB. The molecularly confirmed <jats:italic>Aspergillus<\/jats:italic> species were <jats:italic>A. flavus<\/jats:italic>, <jats:italic>A. fumigatus<\/jats:italic> and <jats:italic>A. ochraceus<\/jats:italic>. The sensitivity and specificity of BAL GM \u2265 0.5 in old PTB patients with fungus ball were 100%, 41.5%, respectively. The statistical analysis of the mean \u00b1 SEM of BAL GM levels was demonstrated a higher levels of GM in patients with fungus ball\/aspergilloma compared to old PTB patients without fungus ball\/aspergilloma. The optimal cut\u2010off value for BAL GM was determined as 0.50 by ROC curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our results, we can recommend the detection of GM in BAL samples as a diagnostic approach for fungus ball in PTB patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13099","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:10:20Z","timestamp":1589008220000},"page":"755-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Galactomannan detection in bronchoalveolar lavage fluids: A diagnostic approach for fungus ball in patients with pulmonary tuberculosis?"],"prefix":"10.1111","volume":"63","author":[{"given":"Maryam","family":"Gheisari","sequence":"first","affiliation":[{"name":"Invasive Fungi Research Center\/Department of Medical mycology School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Basharzad","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Intensive Care Labbafinejad Hospital Shaheed Beheshti University of Medical Science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshid","family":"Yazdani Charati","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Health Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam Sadat","family":"Mirenayat","sequence":"additional","affiliation":[{"name":"Lung Transplantation Research Center (LTRC) National Research Institute of Tuberculosis and Lung Diseases (NIRTLD) Shaheed Beheshti University of Medical Sciences Tehran 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Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-4648","authenticated-orcid":false,"given":"Mohammad T.","family":"Hedayati","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center\/Department of Medical mycology School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00054810"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"202","article-title":"Aspergilloma and the surgeon","volume":"6","author":"Moodley L","year":"2014","journal-title":"J Thorac 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