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Six of the analysed isolates had fluconazole MICs\u00a0\u2265\u00a032\u00a0\u00b5g\/mL; of them, five harboured unique <jats:italic>PDR1<\/jats:italic> mutations. Although echinocandin resistance was not detected, three isolates had mutations in HS1\u2010Fks1 (S629T, n\u00a0=\u00a01) and HS1\u2010Fks2 (S663P, n\u00a0=\u00a02); one of the latter was also fluconazole\u2010resistant. All patients infected with isolates carrying HS\u2010<jats:italic>FKS<\/jats:italic> mutations and\/or demonstrating fluconazole MIC\u00a0\u2265\u00a032\u00a0\u00b5g\/mL (except one without clinical data) showed therapeutic failure (TF) with echinocandin and fluconazole; seven such isolates were collected in Ege (n\u00a0=\u00a04) and Gulhane (n\u00a0=\u00a03) hospitals and six detected recently. Among 34 identified genotypes, none were associated with mortality or enriched for fluconazole\u2010resistant isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antifungal susceptibility testing should be supplemented with HS\u2010<jats:italic>FKS<\/jats:italic> sequencing to predict TF for echinocandins, whereas fluconazole MIC\u00a0\u2265\u00a032\u00a0\u00b5g\/mL may predict TF. Recent emergence of <jats:italic>C glabrata<\/jats:italic> isolates associated with antifungal TF warrants future comprehensive prospective studies in Turkey.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13104","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T06:23:45Z","timestamp":1589610225000},"page":"911-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Low level of antifungal resistance of <i>Candida glabrata<\/i> blood isolates in Turkey: Fluconazole minimum inhibitory concentration and <i>FKS<\/i> mutations can predict therapeutic failure"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-4841","authenticated-orcid":false,"given":"Amir","family":"Arastehfar","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory Molecular Medical Mycology Shanghai China"},{"name":"Westerdijk Fungal Biodiversity Institute Utrecht The 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