{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:25:42Z","timestamp":1784917542306,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal disease is a significant cause of morbidity and mortality in immunosuppressed children. The recognition of patients at risk for candidaemia is paramount to a better prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize <jats:italic>Candida spp<\/jats:italic> bloodstream infections (BSI) in a reference centre for paediatric oncology and to describe the most prevalent risk factors associated with candida infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This is a retrospective cohort study carried out with paediatric patients followed up with at the Institute of Pediatric Oncology, Brazil, who presented positive blood culture for <jats:italic>Candida spp<\/jats:italic> from January 2004 to December 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety episodes of candidaemia were analysed; patients had a median age of 4.5\u00a0years, and 57.8% were males, with a diagnosis of solid tumours in 54.5% of cases. The most common <jats:italic>Candida<\/jats:italic> species were <jats:italic>C\u00a0albicans<\/jats:italic> (35.6%), <jats:italic>C\u00a0parapsilosis<\/jats:italic> (30.0%) and <jats:italic>C\u00a0tropicalis<\/jats:italic> (16.7%). <jats:italic>C\u00a0tropicalis<\/jats:italic> BSI was associated with neutropenia and skin lesions. Therapy was successful in 67.1% of the episodes. Older age and thrombocytopenia were associated with therapeutic failure. Death within 30\u00a0days occurred in 24.4% of patients; predictive factors were older age and admission to an ICU <jats:italic>C\u00a0parapsilosis<\/jats:italic> candidaemia was a protective factor for death when compared to <jats:italic>C\u00a0albicans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The main species isolated were <jats:italic>C\u00a0albicans<\/jats:italic>, <jats:italic>C\u00a0parapsilosis<\/jats:italic> and <jats:italic>C\u00a0tropicalis<\/jats:italic>. <jats:italic>C\u00a0tropicalis<\/jats:italic> BSI was associated with neutropenia and skin lesions. The death rate was significant, and a worse prognosis was associated with older age, thrombocytopenia and admission to an ICU <jats:italic>C\u00a0parapsilosis<\/jats:italic> infection proved to be a protective factor against mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13106","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T21:57:04Z","timestamp":1589925424000},"page":"812-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Candida spp<\/i> bloodstream infections in a Latin American Pediatric Oncology Reference Center: Epidemiology and associated factors"],"prefix":"10.1111","volume":"63","author":[{"given":"Adriana Maria","family":"Paixao de Sousa da Silva","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases Federal University of Sao Paulo Sao Paulo Brazil"},{"name":"Institute of Pediatric Oncology Grupo de Apoio ao Adolescente e 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