{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:16:10Z","timestamp":1791260170336,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candidaemia is an important infectious complication for haematological malignancy patients. Antifungal prophylaxis reduces the incidence of candidaemia but may be associated with breakthrough candidaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse the <jats:italic>Candida<\/jats:italic> species\u2019 distribution and relative antifungal susceptibility profiles of candidaemia episodes in relation to the use of antifungal prophylaxis among Italian SEIFEM haematology centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This multicentre retrospective observational SEIFEM study included 133 single\u2010species candidaemia episodes of haematological malignancy patients for whom antifungal susceptibility testing results of blood <jats:italic>Candida<\/jats:italic> isolates were available between 2011 and 2015. Each participating centre provided both clinical and microbiological data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010<jats:italic>Candida albicans Candida<\/jats:italic> (NCAC) species were the mostly isolated species (89, 66.9%), which accounted for <jats:italic>C\u00a0parapsilosis<\/jats:italic> (35, 26.3%), <jats:italic>C\u00a0glabrata<\/jats:italic> (16, 12.0%), <jats:italic>C\u00a0krusei<\/jats:italic> (14, 10.5%), <jats:italic>C\u00a0tropicalis<\/jats:italic> (13, 9.8%) and uncommon species (11, 8.3%). <jats:italic>C\u00a0albicans<\/jats:italic> caused the remaining 44 (33.1%) episodes. Excluding 2 <jats:italic>C\u00a0albicans<\/jats:italic> isolates, 23 of 25 fluconazole\u2010resistant isolates were NCAC species (14 <jats:italic>C\u00a0krusei<\/jats:italic>, 6 <jats:italic>C\u00a0glabrata<\/jats:italic>, 2 <jats:italic>C\u00a0parapsilosis<\/jats:italic> and 1 <jats:italic>C\u00a0tropicalis<\/jats:italic>). Fifty\u2010six (42.1%) of 133 patients developed breakthrough candidaemia. Systemic antifungal prophylaxis consisted of azoles, especially fluconazole and posaconazole, in 50 (89.3%) of 56 patients in whom a breakthrough candidaemia occurred. Interestingly, all these patients tended to develop a <jats:italic>C\u00a0krusei<\/jats:italic> infection (10\/56, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) or a fluconazole\u2010resistant isolate\u2019s infection (14\/50, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) compared to patients (4\/77 and 10\/77, respectively) who did not have a breakthrough candidaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optimisation of prophylactic strategies is necessary to limit the occurrence of breakthrough candidaemia and, importantly, the emergence of fluconazole\u2010resistant NCAC isolates\u2019 infections in haematological malignancy patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13130","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T22:03:33Z","timestamp":1591999413000},"page":"900-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Candidaemia in haematological malignancy patients from a SEIFEM study: Epidemiological patterns according to antifungal prophylaxis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1663-7546","authenticated-orcid":false,"given":"Brunella","family":"Posteraro","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Gastroenterologiche, Endocrino\u2010Metaboliche e Nefro\u2010Urologiche Fondazione Policlinico Universitario A. 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