{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:29:12Z","timestamp":1793035752868,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["99\u20101\u201099\u201047198"],"award-info":[{"award-number":["99\u20101\u201099\u201047198"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emergence of coronavirus disease 2019 (COVID\u201019) is a major healthcare threat. Apparently, the novel coronavirus (SARS\u2010CoV\u20102) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID\u201019 patients with a list of attributable risk factors for oral infections has not yet been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We here aim to investigate the prevalence, causative agents and antifungal susceptibility pattern of OPC in Iranian COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 53 hospitalised COVID\u201019 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21\u2010plex PCR and sequencing of the internal transcribed spacer region (ITS1\u20105.8S\u2010ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 53 COVID\u201019 patients with OPC, cardiovascular diseases (52.83%) and diabetes (37.7%) were the principal underlying conditions. The most common risk factor was lymphopaenia (71%). In total, 65\n                      <jats:italic>Candida<\/jats:italic>\n                      isolates causing OPC were recovered.\n                      <jats:italic>C\u00a0albicans<\/jats:italic>\n                      (70.7%) was the most common, followed by\n                      <jats:italic>C\u00a0glabrata<\/jats:italic>\n                      (10.7%),\n                      <jats:italic>C\u00a0dubliniensis<\/jats:italic>\n                      (9.2%),\n                      <jats:italic>C\u00a0parapsilosis<\/jats:italic>\n                      sensu stricto (4.6%),\n                      <jats:italic>C\u00a0tropicalis<\/jats:italic>\n                      (3%) and\n                      <jats:italic>Pichia kudriavzevii<\/jats:italic>\n                      (=\n                      <jats:italic>C\u00a0krusei<\/jats:italic>\n                      , 1.5%). Majority of the\n                      <jats:italic>Candida<\/jats:italic>\n                      isolates were susceptible to all three classes of antifungal drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID\u201019 patients. Further studies should be conducted to design an appropriate prophylaxis programme and improve management of OPC in critically ill COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13137","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T16:04:47Z","timestamp":1593619487000},"page":"771-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Oropharyngeal candidiasis in hospitalised COVID\u201019 patients from Iran: Species identification and antifungal susceptibility pattern"],"prefix":"10.1111","volume":"63","author":[{"given":"Mohammadreza","family":"Salehi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine Imam Khomeini Hospital complex Tehran University of Medical Sciences Tehran 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