{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:20:17Z","timestamp":1769246417174,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the antifungal susceptibility of <jats:italic>Sporothrix globosa<\/jats:italic> isolated from Shandong, China, and compare the differences of antifungal activity in vitro between yeast and mycelial phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The in vitro sensitivity of mycelium phase and yeast phase of <jats:italic>Sporothrix globosa to<\/jats:italic> anidulafungin, micafungin, caspofungin, 5\u2010flucytosine, posaconazole, voriconazole, itraconazole, fluconazole and amphotericin B was tested by Sensititre\u2122 YeastOne\u2122. The minimum inhibitory concentration (MIC) values of mycelium phase and yeast phase were calculated. SPSS 19.0 software was used to conduct non\u2010parametric rank sum test for MIC values, and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mycelium phase and yeast phase were the most sensitive to itraconazole and the least sensitive to fluconazole. The yeast phase of the same strain was more sensitive to itraconazole, voriconazole, posaconazole, micafungin, anidulafungin, caspofungin and 5\u2010fluorouracil, compared with the mycelium (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). However, fluconazole and amphotericin B had no significant difference in mycelium phase and yeast phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Itraconazole is the most active antifungal agent in vitro against <jats:italic>S\u00a0globosa<\/jats:italic>. The yeast phase of the same strain is more sensitive than that of the mycelium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13141","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T12:55:22Z","timestamp":1594558522000},"page":"1191-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Susceptibility testing of clinical isolates of <i>Sporothrix globosa<\/i> in Shandong, China"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-7242","authenticated-orcid":false,"given":"Fangfang","family":"Bao","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Pan","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1007\/s11046-020-00425-0","article-title":"The threat of emerging and re\u2010emerging pathogenic Sporothrix species","author":"Rodrigues AM","year":"2020","journal-title":"Mycopathologia"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/272376"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2603.190803"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-018-0310-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13045"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/w06-040"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2015.03.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12895"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00808-07"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02824.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-013-9668-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1300136"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy163"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01176-06"},{"issue":"3","key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/jof4030086","article-title":"Molecular identification, antifungal susceptibility, and geographic origin of clinical strains of Sporothrix schenckii complex in Mexico","volume":"4","author":"Rojas OC","year":"2018","journal-title":"J Fungi (Basel)"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"56","article-title":"Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil","volume":"52","author":"Ottonelli Stopiglia CD","year":"2014","journal-title":"Med Mycol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01701.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12760"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.2017279"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.13141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:38:31Z","timestamp":1693903111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/myc.13141"],"URL":"https:\/\/doi.org\/10.1111\/myc.13141","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}