{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:20:02Z","timestamp":1789705202649,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology, clinical profile and outcome of paediatric candidemia vary considerably by age, healthcare settings and prevalent <jats:italic>Candida<\/jats:italic> species. Despite these differences, few comprehensive studies are undertaken. This nationwide study addresses this knowledge gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>487 children who contracted ICU\u2010acquired candidemia at 23 Indian tertiary care centres were assessed for 398 variables spanning demography, clinical characteristics, microbiology, treatment and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both neonates (5.0\u00a0days; range\u00a0=\u00a03.0\u20109.5) and non\u2010neonatal children (7.0\u00a0days; range\u00a0=\u00a03.0\u201013.0) developed candidemia early after ICU admission. Majority of neonates were premature (63.7%) with low birthweight (57.1%). Perinatal asphyxia (7.3%), pneumonia (8.2%), congenital heart disease (8.4%) and invasive procedures were common comorbidities, and antibiotic use (94.1%) was widespread. <jats:italic>C tropicalis<\/jats:italic> (24.7%) and <jats:italic>C albicans<\/jats:italic> (20.7%) dominated both age groups. Antifungal treatment (66.5%) and removal of central catheters (44.8%) lagged behind. Overall resistance was low; however, emergence of resistant <jats:italic>C krusei<\/jats:italic> and <jats:italic>C auris<\/jats:italic> needs attention. The 30\u2010day crude mortality was 27.8% (neonates) and 29.4% (non\u2010neonates). Logistic regression identified admission to public sector ICUs (OR\u00a0=\u00a05.64), mechanical ventilation (OR\u00a0=\u00a02.82), corticosteroid therapy (OR\u00a0=\u00a08.89) and antifungal therapy (OR\u00a0=\u00a00.22) as independent predictors of 30\u2010day crude mortality in neonates. Similarly, admission to public sector ICUs (OR\u00a0=\u00a03.62), mechanical ventilation (OR\u00a0=\u00a03.13), exposure to carbapenems (OR\u00a0=\u00a02.18) and azole antifungal therapy (OR\u00a0=\u00a00.48) were independent predictors for non\u2010neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings reveal a distinct epidemiology, including early infection with a different spectrum of <jats:italic>Candida<\/jats:italic> species, calling for appropriate intervention strategies to reduce candidemia morbidity and mortality. Independent factors identified in our regression models can help tackle these challenges.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13145","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T06:40:48Z","timestamp":1595054448000},"page":"1149-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Characteristics, outcome and risk factors for mortality of paediatric patients with ICU\u2010acquired candidemia in India: A multicentre prospective study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research  Chandigarh 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