{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:43:14Z","timestamp":1775212994986,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute myeloid leukaemia (AML) patients are at high risk of invasive aspergillosis (IA) after first induction chemotherapy (CHT). Although IA risk factors have been identified, few data are available on impact of IA, occurring during induction phase, on overall AML outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and results<\/jats:title><jats:p>The end point of this multicentre, case\u2010control, study was to evaluate whether IA, occurring after first induction CHT, can affect treatment schedule and patient's outcome. We identified 40 AML patients (cases) who developed IA during first induction phase, 31 probable (77.5%) and 9 proven (22.5%). These cases were matched with a control group (80 AML) without IA, balanced according to age, type of CHT, AML characteristics and cytogenetic\u2010molecular risk factors. The overall response rate to induction CHT was the same in the 2 groups. In the 40 cases with IA, the overall response rate to antifungal treatment was favourable (80%) but it was significantly affected by the achievement of leukaemia complete remission (CR) with induction CHT. In fact, in cases with AML responsive to induction CHT, responses of IA to antifungal therapy were 96% compared to 21% in cases of AML not responsive to induction treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). The adherence to the schedule and full doses of CHT were reported in 35% of cases (14\/40) and in 76% of controls (61\/80) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001; OR 6.7; 95% CI 2.7\u201016.6). After first induction CHT, a significant higher number of cases (15\/40; 37.5%) compared to controls (9\/80; 11%) could not receive additional cycles of CHT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0011, OR 4.8; 95% CI 1.9\u201012.3). The IA\u2010related mortality was 22.5%. The median OS of cases was significantly worse than OS of controls with a difference of 12.3\u00a0months (12.1 vs 24.4\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). However, the occurrence of IA during first induction phase did not have a significant impact on the OS of cases who achieved a CR of AML with induction CHT which are able to proceed, despite the IA, with their therapeutic program, achieving the same OS as the control group with AML in CR (<jats:italic>P<\/jats:italic>\u00a0=\u00a0ns).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data show that IA during first induction CHT can delay the subsequent therapeutic program and has a significant impact on OS, specifically in AML patients who did not achieved a CR of AML with the first course of CHT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13147","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T11:03:14Z","timestamp":1595415794000},"page":"1094-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of invasive aspergillosis occurring during first induction therapy on outcome of acute myeloid leukaemia (SEIFEM\u201012B study)"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-1310","authenticated-orcid":false,"given":"Anna","family":"Candoni","sequence":"first","affiliation":[{"name":"Clinica Ematologica Azienda Sanitaria\u2010Universitaria Friuli Centrale (ASUFC) Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Farina","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Perruccio","sequence":"additional","affiliation":[{"name":"Oncoematologia Pediatrica Ospedale SM Misericordia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Di Blasi","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Criscuolo","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ASST\u2010Spedali Civili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Delia","sequence":"additional","affiliation":[{"name":"Sezione di Ematologia Dipartimento dell'Emergenza e dei Trapianti d'Organo\u2010Universit\u00e0 di Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Zannier","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Azienda Sanitaria\u2010Universitaria Friuli Centrale (ASUFC) Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Dragonetti","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Fanci","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Funzionale di Ematologia Azienda Ospedaliero\u2010Universitaria Careggi e Universit\u00e0 di Firenze Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Martino","sequence":"additional","affiliation":[{"name":"UOC Ematologia Ospedale Bianchi Melacrino Morelli Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma 'Tor Vergata' Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Fianchi","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Vianelli","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Dipartimento di Onco\u2010Ematologia Policlinico S. Orsola\u2010Malpighi Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Chierichini","sequence":"additional","affiliation":[{"name":"UOC Ematologia Azienda Ospedaliera S. Giovanni Addolorata Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Garzia","sequence":"additional","affiliation":[{"name":"UOC Ematologia Ospedale San Camillo Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Petruzzellis","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Azienda Sanitaria\u2010Universitaria Friuli Centrale (ASUFC) Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Nadali","sequence":"additional","affiliation":[{"name":"UOC di Ematologia Azienda Ospedaliera Universitaria Integrata di Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Verga","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Ospedale San Gerardo ASST Monza Universit\u00e0 Milano Bicocca Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia Ematologia, A.O.U. Citt\u00e0 della Salute e della Scienza di Torino SSD Trapianto allogenico di Cellule Staminali Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematological malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Hematologica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767110-00004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21776"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.012054"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128410"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2649-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw114"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.113399"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.5.813"},{"issue":"46","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"15","author":"De Pauw B","year":"2008","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197851"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.030825"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1397-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.01.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1613535"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.094359"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.09.002"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fmyc.13147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13147","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13147","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T19:14:38Z","timestamp":1693768478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,23]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/myc.13147"],"URL":"https:\/\/doi.org\/10.1111\/myc.13147","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,23]]},"assertion":[{"value":"2020-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}