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Although this strategy has resulted in an overall reduction in IFIs, a subset of patients develop breakthrough IFIs with substantial morbidity and mortality in this population. Here, we review the most significant risk factors for breakthrough IFIs in haematology patients, solid organ transplant recipients, and patients in the intensive care unit, focusing particularly on host factors, and highlight areas that require future investigation.<\/jats:p>","DOI":"10.1111\/myc.13148","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T06:42:21Z","timestamp":1596436941000},"page":"1021-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":184,"title":["Breakthrough invasive fungal infections: Who is at risk?"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-9587","authenticated-orcid":false,"given":"Jeffrey D.","family":"Jenks","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Division of Infectious Diseases and Global Public Health Department of Medicine University of California San Diego  La Jolla California USA"},{"name":"Clinical and Translational Fungal\u2014Working Group University of California San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine ECMM Center of Excellence for Medical Mycology German Centre for Infection Research Partner Site Bonn\u2010Cologne (DZIF) University of Cologne  Cologne Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln) University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon 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