{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:09:50Z","timestamp":1791500990078,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016\u20100206"],"award-info":[{"award-number":["PICT 2016\u20100206"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020170100147BA"],"award-info":[{"award-number":["UBACyT 20020170100147BA"]}],"id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The emergence of azole resistance in non\u2010<jats:italic>fumigatus Aspergillus<\/jats:italic> strains is on the raise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of <jats:italic>Aspergillus flavus<\/jats:italic> from Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five <jats:italic>A\u00a0flavus<\/jats:italic> isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin B and azole resistance using the standard microbroth dilution method according to CLSI M38\u2010A2 guidelines. Sequencing analysis of the <jats:italic>cyp51<\/jats:italic> genes was conducted in those isolates displaying high MICs values to itraconazole, voriconazole and\/or posaconazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the environmental isolates, 33.3% of them showed high MIC values for at least one triazole whereas 23.5% of the clinical isolates displayed high MIC values for amphotericin B. Point mutations in the <jats:italic>Cyp51C<\/jats:italic> gene were recorded in most environmental isolates with non\u2010wild\u2010type MIC values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Susceptibility differences among environmental <jats:italic>A\u00a0flavus<\/jats:italic> isolates might suggest the possibility of native resistance to certain triazole antifungals used in the clinic. To the best of our knowledge, this is the first report of antifungal screening of environmental strains of <jats:italic>A\u00a0flavus<\/jats:italic> in soybean seeds and chickpea seeds from Argentina that showed increased resistance to voriconazole and itraconazole in comparison to clinical strains.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13193","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T16:49:43Z","timestamp":1601570983000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of <i>Aspergillus flavus<\/i> from Argentina"],"prefix":"10.1111","volume":"64","author":[{"given":"Katherine","family":"Hermida\u2010Alava","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda 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