{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:33:00Z","timestamp":1791977580295,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Griseofulvin and terbinafine are considered effective first\u2010line therapies for tinea capitis (TC). Haematological dyscrasias and hepatic injury are possible adverse effects with both drugs. There is a debate in the literature regarding the necessity of laboratory monitoring during griseofulvin and terbinafine treatment. We aimed at assessing the prevalence and severity of haematological and hepatic laboratory test abnormalities in a paediatric cohort of African immigrants in Tel\u2010Aviv with TC who were treated with Terbinafine or Griseofulvin. We conducted a retrospective study of all TC cases diagnosed and treated at the paediatric dermatology clinic, Tel\u2010Aviv Medical centre, between June 2013 and March 2019. Epidemiologic, clinical and laboratory data were collected. Our cohort included 321 patients of whom 225 (70%) were treated with Griseofulvin and 96 (30%) with Terbinafine. We identified a total of 64 (20%) patients with haematological or hepatic laboratory test abnormalities that in most cases (96.3%) were considered as mild. No difference in laboratory abnormalities prevalence was identified between the griseofulvin and terbinafine groups (21.3% and 16.6%, respectively). Only one patient treated with Griseofulvin revealed significantly increased levels of hepatic aminotransferases that required discontinuation of treatment. Mild elevation in hepatic transaminases is relatively common among paediatric patients treated with systemic antifungal treatment for TC. However, significant laboratory abnormalities are extremely rare and may be diagnosed and addressed early through periodic laboratory tests monitoring.<\/jats:p>","DOI":"10.1111\/myc.13197","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T18:47:18Z","timestamp":1602874038000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laboratory monitoring during antifungal treatment of paediatric tinea capitis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-3108","authenticated-orcid":false,"given":"Natalie","family":"Aleohin","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-9416","authenticated-orcid":false,"given":"Jonathan","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efrat","family":"Bar\u2010Ilan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Samuelov","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"},{"name":"Pediatric Dermatology Clinic Tel\u2010Aviv Sourasky Medical Center Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"},{"name":"Pediatric Dermatology Clinic Tel\u2010Aviv Sourasky Medical Center Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-2932","authenticated-orcid":false,"given":"Jacob","family":"Mashiah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"},{"name":"Pediatric Dermatology Clinic Tel\u2010Aviv Sourasky Medical Center Dana\u2010Dwek Children's Hospital Tel\u2010Aviv Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90013-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04022.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.01978.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1041"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00691.x"},{"key":"e_1_2_8_8_1","volume-title":"Griseofulvin Oral Tablets [package insert]","author":"Valeant Pharmaceuticals North America LLC","year":"2016"},{"key":"e_1_2_8_9_1","volume-title":"Terbinafine Hcl Oral Granules [package insert]","author":"Lamisil Oral Granules","year":"2017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-008-9109-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.4483"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.3578"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12501"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12970"},{"key":"e_1_2_8_15_1","unstructured":"US Department of Health and Human Services.Common terminology criteria for adverse events (CTCAE). 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