{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:30:10Z","timestamp":1787628610896,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Malassezia<\/jats:italic> species are associated with several common dermatologic conditions including pityriasis versicolor, seborrhoeic dermatitis, folliculitis, and atopic dermatitis and dandruff. However, its causal role remains to be established. We intended to explore the role of inflammasome activation in human keratinocytes in response to three different <jats:italic>Malassezia<\/jats:italic> species. We compared the different activation patterns of inflammasomes and the expression of pro\u2010inflammatory cytokines and antimicrobial peptides by three different <jats:italic>Malassezia<\/jats:italic> species\u2014<jats:italic>M. restricta<\/jats:italic>, <jats:italic>M. globosa<\/jats:italic> and <jats:italic>M. sympodialis<\/jats:italic>\u2014in human keratinocytes. We found that different <jats:italic>Malassezia<\/jats:italic> species, especially <jats:italic>M. restricta<\/jats:italic> and <jats:italic>M. globosa<\/jats:italic> could induce nucleotide\u2010binding oligomerisation domain, leucine\u2010rich repeat and pyrin\u2010domain\u2010containing protein (NLRP)3\u2013apoptosis\u2010associated speck\u2010like protein containing CARD (ASC) inflammasome activation and subsequent interleukin (IL)\u20101\u03b2 secretion in human keratinocytes. <jats:italic>Malassezia<\/jats:italic> species variably induced thymic stromal lymphopoietin, \u03b2\u2010defensin 2, and LL\u201037. IL\u20108 mRNA and IL\u201022 protein significantly increased in the <jats:italic>M.\u00a0sympodialis<\/jats:italic>\u2010treated group, and Chemokine C\u2013C motif ligand (CCL)17 and CCL22 mRNA were increased in response to <jats:italic>M.\u00a0globosa<\/jats:italic>\u2010 and <jats:italic>M.\u00a0restricta<\/jats:italic>\u2010 treated keratinocytes, respectively. Our data show that various species of <jats:italic>Malassezia<\/jats:italic> promote variable inflammatory responses in keratinocytes by activating NLRP3 inflammasomes, pro\u2010inflammatory cytokines and chemokines, and antimicrobial peptides.<\/jats:p>","DOI":"10.1111\/myc.13214","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T23:39:46Z","timestamp":1605742786000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Inflammasome\u2010mediated Inflammation by Malassezia in human keratinocytes: A comparative analysis with different strains"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-2808","authenticated-orcid":false,"given":"Hye Ree","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Eunpyeong St. Mary\u2019s Hospital The Catholic University of Korea  Seoul 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Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1248","authenticated-orcid":false,"given":"Yang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Konkuk University School of Medicine  Seoul Korea"},{"name":"Research Institute of Medical Science Konkuk University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-5645","authenticated-orcid":false,"given":"Seongju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Hypoxia\u2010related Disease Research Center College of Medicine Inha University  Incheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9822-4760","authenticated-orcid":false,"given":"Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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