{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:21Z","timestamp":1787015781240,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucormycosis is a rare, invasive disease associated with high mortality rates, produced by opportunistic pathogens related to the Mucorales order and characterised by a diverse range of clinical forms; acute rhino\u2010orbital\u2010cerebral and pulmonary symptoms are the most reported ones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the experience of mucormycosis observed in a tertiary\u2010care hospital in Mexico for 35\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, descriptive and observational study on mucormycosis at a tertiary\u2010care hospital in Mexico from January 1985 to December 2019. Demographic and clinical data and mycological and histopathological records were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred fourteen proven cases of mucormycosis for 35\u00a0years at a tertiary\u2010care hospital in Mexico were included. Most of the cases were male patients with a median age of 45\u00a0years. The two most associated underlying diseases were diabetes mellitus (76.6%) and haematologic malignancy (15.4%). The three primary clinical forms were as follows: rhino\u2010orbito\u2010cerebral (75.9%), cutaneous (8.41%) and pulmonary (7.47%) mucormycosis. The most isolated agents were\n                      <jats:italic>Rhizopus arrhizus<\/jats:italic>\n                      (58.4%) and\n                      <jats:italic>Lichtheimia corymbifera<\/jats:italic>\n                      (12.3%). The overall therapeutic response was 58.5%, and the best response was observed with amphotericin B deoxycholate and surgical debridement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Mucormycosis is an emerging disease, and its incidence has increased at our hospital over the years. In this study, the rhino\u2010cerebral clinical type was the most frequent in patients with uncontrolled diabetes; the main aetiological agent was\n                      <jats:italic>R.\u00a0arrhizus<\/jats:italic>\n                      . Early diagnosis, control of the underlying disease and prompt management may increase the survival rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13222","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T15:00:18Z","timestamp":1606748418000},"page":"372-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Mucormycosis at a tertiary\u2010care center in Mexico. A 35\u2010year retrospective study of 214 cases"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-3317","authenticated-orcid":false,"given":"Alexandro","family":"Bonifaz","sequence":"first","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-1619","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Tirado\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Hern\u00e1ndez\u2010Medel","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City 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F.","family":"Mois\u00e9s\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Paredes\u2010Farrera","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"G\u00f3mez\u2010Apo","sequence":"additional","affiliation":[{"name":"Hospital General de M\u00e9xico \u201cDr. Eduardo Liceaga\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-6556","authenticated-orcid":false,"given":"Rogelio de J.","family":"Trevi\u00f1o\u2010Rangel","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\" Universidad 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